Q5NCH9 · GRM6_MOUSE
- ProteinMetabotropic glutamate receptor 6
- GeneGrm6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids871 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).
Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.
Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 148 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 169-171 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: AST | ||||||
Binding site | 219 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 301 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 394 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMetabotropic glutamate receptor 6
- Short namesmGluR6
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5NCH9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane (By similarity).
Detected at dendritic tips of bipolar cells
Detected at dendritic tips of bipolar cells
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 24-579 | Extracellular | ||||
Sequence: AGSVRLAGGLTLGGLFPVHARGAAGRACGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGEEASVRCPGGVPPLRAAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPW | ||||||
Transmembrane | 580-602 | Helical; Name=1 | ||||
Sequence: AALPLLLAVLGIMATTTIIATFM | ||||||
Topological domain | 603-616 | Cytoplasmic | ||||
Sequence: RHNDTPIVRASGRE | ||||||
Transmembrane | 617-637 | Helical; Name=2 | ||||
Sequence: LSYVLLTGIFLIYAITFLMVA | ||||||
Topological domain | 638-648 | Extracellular | ||||
Sequence: EPCAAVCASRR | ||||||
Transmembrane | 649-667 | Helical; Name=3 | ||||
Sequence: LLLGLGTTLSYSALLTKTN | ||||||
Topological domain | 668-691 | Cytoplasmic | ||||
Sequence: RIYRIFEQGKRSVTPPPFISPTSQ | ||||||
Transmembrane | 692-712 | Helical; Name=4 | ||||
Sequence: LVITFGLTSLQVVGVIAWLGA | ||||||
Topological domain | 713-742 | Extracellular | ||||
Sequence: QPPHSVIDYEEQRTVDPEQARGVLKCDMSD | ||||||
Transmembrane | 743-764 | Helical; Name=5 | ||||
Sequence: LSLIGCLGYSLLLMVTCTVYAI | ||||||
Topological domain | 765-777 | Cytoplasmic | ||||
Sequence: KARGVPETFNEAK | ||||||
Transmembrane | 778-800 | Helical; Name=6 | ||||
Sequence: PIGFTMYTTCIIWLAFVPIFFGT | ||||||
Topological domain | 801-813 | Extracellular | ||||
Sequence: AQSAEKIYIQTTT | ||||||
Transmembrane | 814-839 | Helical; Name=7 | ||||
Sequence: LTVSLSLSASVSLGMLYVPKTYVILF | ||||||
Topological domain | 840-871 | Cytoplasmic | ||||
Sequence: HPEQNVQKRKRSLKKTSTMAAPPKSENSEDAK |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Retinal cells from mutant mice display a subtly altered response to cycles of light and darkness, due to a failure of the ON bipolar cells in the retina to become depolarized in response to light. As a consequence, mutant mice display little or no pupillary contraction in adaptation to low light intensity. Besides, they exhibit strongly impaired responses to moving stimuli, and fail to produce a response when the visual constrast is low. Besides, rod bipolar cells from mutant mice lack TRPM1 channel activity.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 33 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MGRLRVLLLWLAWWLSQAGIAHG | ||||||
Chain | PRO_0000012935 | 24-871 | Metabotropic glutamate receptor 6 | |||
Sequence: AGSVRLAGGLTLGGLFPVHARGAAGRACGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGEEASVRCPGGVPPLRAAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIIATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAVCASRRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPKSENSEDAK | ||||||
Disulfide bond | 51↔93 | |||||
Sequence: CGTLKKEQGVHRLEAMLYALDRINADPELLPGVRLGARLLDTC | ||||||
Disulfide bond | 238↔530 | |||||
Sequence: CIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPC | ||||||
Glycosylation | 290 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 361↔377 | |||||
Sequence: CKLTSSGGQSDDSTRKC | ||||||
Disulfide bond | 417↔424 | |||||
Sequence: CPGHTGLC | ||||||
Glycosylation | 445 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 473 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 512↔531 | |||||
Sequence: CSLPCGPGERKKMVKGVPCC | ||||||
Disulfide bond | 516↔534 | |||||
Sequence: CGPGERKKMVKGVPCCWHC | ||||||
Disulfide bond | 537↔549 | |||||
Sequence: CDGYRFQVDEFTC | ||||||
Disulfide bond | 552↔565 | |||||
Sequence: CPGHMRPTPNHTGC | ||||||
Glycosylation | 561 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in the outer plexiform layer in retina (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 848-871 | Disordered | ||||
Sequence: RKRSLKKTSTMAAPPKSENSEDAK |
Sequence similarities
Belongs to the G-protein coupled receptor 3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length871
- Mass (Da)95,193
- Last updated2005-02-01 v1
- ChecksumFB07056ABA7B259D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL627215 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |