Q5MKB7 · Q5MKB7_9PEZI

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin
Biological ProcessrRNA transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 115683
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Cladosporiales > Cladosporiaceae > Cladosporium

Accessions

  • Primary accession
    Q5MKB7

Subcellular Location

Keywords

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-34Disordered
Domain3-112Histone H2A/H2B/H3

Sequence similarities

Belongs to the histone H3 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    112
  • Mass (Da)
    12,566
  • Last updated
    2007-08-21 v2
  • Checksum
    88510A8ADDEFEBDE
RSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue112

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY752255
EMBL· GenBank· DDBJ
AAW29629.2
EMBL· GenBank· DDBJ
Genomic DNA
EF679640
EMBL· GenBank· DDBJ
ABV29066.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679645
EMBL· GenBank· DDBJ
ABV29071.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679646
EMBL· GenBank· DDBJ
ABV29072.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679648
EMBL· GenBank· DDBJ
ABV29074.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679650
EMBL· GenBank· DDBJ
ABV29076.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679653
EMBL· GenBank· DDBJ
ABV29079.1
EMBL· GenBank· DDBJ
Genomic DNA
EF679654
EMBL· GenBank· DDBJ
ABV29080.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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