Q5M9H2 · Q5M9H2_RAT
- ProteinVery long-chain specific acyl-CoA dehydrogenase, mitochondrial
- GeneAcadvl
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids655 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- H+ + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- H+ + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- dodecanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- eicosanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; mitochondrial fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial nucleoid | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | identical protein binding | |
Molecular Function | long-chain fatty acyl-CoA dehydrogenase activity | |
Molecular Function | very-long-chain fatty acyl-CoA dehydrogenase activity | |
Biological Process | epithelial cell differentiation | |
Biological Process | fatty acid beta-oxidation using acyl-CoA dehydrogenase | |
Biological Process | negative regulation of fatty acid biosynthetic process | |
Biological Process | negative regulation of fatty acid oxidation | |
Biological Process | regulation of cholesterol metabolic process | |
Biological Process | response to cold | |
Biological Process | temperature homeostasis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery long-chain specific acyl-CoA dehydrogenase, mitochondrial
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ5M9H2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-70 | Disordered | ||||
Sequence: MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAES | ||||||
Compositional bias | 23-42 | Polar residues | ||||
Sequence: RSAALQGQPRPTSAQRLYAS | ||||||
Domain | 104-209 | Acyl-CoA dehydrogenase/oxidase N-terminal | ||||
Sequence: ELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQ | ||||||
Domain | 213-315 | Acyl-CoA oxidase/dehydrogenase middle | ||||
Sequence: AFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGV | ||||||
Domain | 327-473 | Acyl-CoA dehydrogenase/oxidase C-terminal | ||||
Sequence: GDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVA | ||||||
Domain | 527-646 | ACAD9/ACADV-like C-terminal | ||||
Sequence: PELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGG |
Sequence similarities
Belongs to the acyl-CoA dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length655
- Mass (Da)70,821
- Last updated2005-02-01 v1
- Checksum42333237EE459513
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P45953 | ACADV_RAT | Acadvl | 655 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-42 | Polar residues | ||||
Sequence: RSAALQGQPRPTSAQRLYAS |
Keywords
- Technical term