Q5M9G0 · DCTD_RAT
- ProteinDeoxycytidylate deaminase
- GeneDctd
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids178 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP).
Catalytic activity
- dCMP + H+ + H2O = dUMP + NH4+This reaction proceeds in the forward direction.
- 5-hydroxymethyl-dCMP + H+ + H2O = 5-hydroxymethyl-dUMP + NH4+This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dCMP deaminase activity | |
Molecular Function | deoxyribonucleoside 5'-monophosphate N-glycosidase activity | |
Molecular Function | identical protein binding | |
Molecular Function | zinc ion binding | |
Biological Process | cytidine deamination | |
Biological Process | nucleoside salvage | |
Biological Process | nucleotide biosynthetic process | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxycytidylate deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ5M9G0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000171694 | 1-178 | Deoxycytidylate deaminase | |||
Sequence: MSDISCKKRDDYLEWPEYFMAVAFLSAQRSKDPSSQVGACIVNTENKIVGIGYNGMPNGCSDDLLPWRRTAENKLDTKYPYVCHAELNAIMNKNSADVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSEETTAARLLFKLAGVTFRKFTPKYSKIVIDFDSINSRPSQKPQ | ||||||
Modified residue | 174 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-145 | CMP/dCMP-type deaminase | ||||
Sequence: EWPEYFMAVAFLSAQRSKDPSSQVGACIVNTENKIVGIGYNGMPNGCSDDLLPWRRTAENKLDTKYPYVCHAELNAIMNKNSADVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSEETTAARLLF |
Sequence similarities
Belongs to the cytidine and deoxycytidylate deaminase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length178
- Mass (Da)20,059
- Last updated2005-02-01 v1
- ChecksumA53ED5C676965029
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3ZXS5 | D3ZXS5_RAT | Dctd | 173 | ||
A0A8I6B368 | A0A8I6B368_RAT | Dctd | 103 | ||
A0A8I6ATK1 | A0A8I6ATK1_RAT | Dctd | 134 | ||
A0A8I6AUD8 | A0A8I6AUD8_RAT | Dctd | 101 | ||
A0A0A0MXX3 | A0A0A0MXX3_RAT | Dctd | 184 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC087138 EMBL· GenBank· DDBJ | AAH87138.1 EMBL· GenBank· DDBJ | mRNA |