Q5KWS3 · Q5KWS3_GEOKA

Function

function

In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

Catalytic activity

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTP diphosphokinase activity
Biological Processguanosine tetraphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP pyrophosphokinase
  • EC number
  • Alternative names
    • (p)ppGpp synthase
    • ATP:GTP 3'-pyrophosphotransferase
    • ppGpp synthase I

Gene names

    • Ordered locus names
      GK2578

Organism names

Accessions

  • Primary accession
    Q5KWS3

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-149HD
Domain391-452TGS
Domain656-731ACT

Sequence similarities

Belongs to the relA/spoT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    732
  • Mass (Da)
    84,417
  • Last updated
    2005-02-01 v1
  • Checksum
    18CC13935EE1E295
MANEQVLTAEQVFERASCYLSEQDVAFLKKAYEFAKHAHRDQFRKSGEPYIIHPIQVAGILVDLKMDATTIAAGFLHDVIEDTEATKEDLEREFGAEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFLAMAQDIRVILIKLADRLHNMRTLKHLPAEKQRRIANETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAEREQYLEEVIQEVRERLNEVHIPCEISGRPKHIYSIYRKMVMQNKQFNEIYDLLAVRIIVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGEPLEVQIRTFEMHQIAEFGIAAHWAYKEGKTIKPNSFEEKLSWFREILEWQNDASNAEEFMESLKMDLFSDMVFVFTPKGDVIELPAGSVPIDFAYRIHSEIGNKTIGAKVNGKMVPLDYKLQTGDIVEILTSNHSYGPSQDWLKLAKTSQARNKIRQFFKKQRREENIEKGKEMVEKEVRSLGFEPKEVMTADNVKRVAEKFNFSNEDDMYAAVGYHGITAAQIAHRLTEKWRKQRDLEEQQRKLAEAVFEAKLPAGKKRDCGIRVQGMDNLLIRLSRCCNPVPGDEIIGFITRGRGISVHRADCPNVKTEEAADRLIAVEWESGANGEREYNVDIEITGFDRRGLLNEVLQAVNETRTDISAVSGRSDHRHKIATIHMTIAIHNLSHLQKVVERIKQIPDIYSVQRLMNN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000043
EMBL· GenBank· DDBJ
BAD76863.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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