Q5KU39 · VPS41_MOUSE

  • Protein
    Vacuolar protein sorting-associated protein 41 homolog
  • Gene
    Vps41
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (By similarity).
Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity).
Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity).
May play a role in HOPS-independent function in the regulated secretory pathway (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentAP-3 adaptor complex
Cellular Componentclathrin complex
Cellular Componentclathrin-coated vesicle
Cellular Componentcytosol
Cellular Componentearly endosome
Cellular Componentearly endosome membrane
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi-associated vesicle
Cellular ComponentHOPS complex
Cellular Componentlate endosome
Cellular Componentlate endosome membrane
Cellular Componentlysosomal HOPS complex
Cellular Componentlysosome
Cellular Componentmicrotubule cytoskeleton
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmicrotubule binding
Biological Processcellular response to starvation
Biological Processendosomal vesicle fusion
Biological Processendosome to lysosome transport
Biological Processlate endosome to lysosome transport
Biological Processmacroautophagy
Biological Processprotein targeting to vacuole
Biological Processregulated exocytosis
Biological Processvesicle-mediated transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting-associated protein 41 homolog
  • Alternative names
    • VAM2 homolog (mVAM2)

Gene names

    • Name
      Vps41

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • C3H/HeJ
    • Czech II
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5KU39
  • Secondary accessions
    • Q05AE9
    • Q3TPS1
    • Q80V99
    • Q8BKK6
    • Q8CG01
    • Q8CJC3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002530201-853Vacuolar protein sorting-associated protein 41 homolog

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41. Interacts with RILP, MON1B. Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes. In vitro can self-assemble into a lattice. Associates with adapter protein complex 3 (AP-3) and clathrin:AP-3 complexes. Interacts with STX17; this interaction is increased in the absence of TMEM39A. Interacts with ARL8B and PLEKHM1; the interaction mediates the recruitment of the HOPS complex to lysosomes. Interacts with RAB7, RAB2A and RAB2B (PubMed:28063257).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, repeat, zinc finger.

TypeIDPosition(s)Description
Compositional bias1-25Acidic residues
Region1-32Disordered
Region1-539Interaction with ARL8B
Repeat567-711CHCR
Zinc finger790-838RING-type; atypical

Sequence similarities

Belongs to the VPS41 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    853
  • Mass (Da)
    98,602
  • Last updated
    2005-02-15 v1
  • Checksum
    A4D54AA7C5D0F2DD
MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKNRGPGSAILEMKK

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-25Acidic residues
Sequence conflict16in Ref. 3; BAE37664
Sequence conflict190in Ref. 3; BAC34707
Sequence conflict401in Ref. 2; AAN73032
Sequence conflict427-428in Ref. 2; AAN73032

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB028843
EMBL· GenBank· DDBJ
BAD88410.1
EMBL· GenBank· DDBJ
mRNA
AF327407
EMBL· GenBank· DDBJ
AAN73032.1
EMBL· GenBank· DDBJ
mRNA
AK051658
EMBL· GenBank· DDBJ
BAC34707.1
EMBL· GenBank· DDBJ
mRNA
AK164177
EMBL· GenBank· DDBJ
BAE37664.1
EMBL· GenBank· DDBJ
mRNA
BC023243
EMBL· GenBank· DDBJ
AAH23243.1
EMBL· GenBank· DDBJ
mRNA
BC049916
EMBL· GenBank· DDBJ
AAH49916.1
EMBL· GenBank· DDBJ
mRNA
BC119362
EMBL· GenBank· DDBJ
AAI19363.1
EMBL· GenBank· DDBJ
mRNA
BC125299
EMBL· GenBank· DDBJ
AAI25300.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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