Q5KU39 · VPS41_MOUSE
- ProteinVacuolar protein sorting-associated protein 41 homolog
- GeneVps41
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids853 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (By similarity).
Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity).
Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity).
May play a role in HOPS-independent function in the regulated secretory pathway (By similarity).
Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (By similarity).
Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity).
May play a role in HOPS-independent function in the regulated secretory pathway (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | AP-3 adaptor complex | |
Cellular Component | clathrin complex | |
Cellular Component | clathrin-coated vesicle | |
Cellular Component | cytosol | |
Cellular Component | early endosome | |
Cellular Component | early endosome membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi-associated vesicle | |
Cellular Component | HOPS complex | |
Cellular Component | late endosome | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal HOPS complex | |
Cellular Component | lysosome | |
Cellular Component | microtubule cytoskeleton | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | microtubule binding | |
Biological Process | cellular response to starvation | |
Biological Process | endosomal vesicle fusion | |
Biological Process | endosome to lysosome transport | |
Biological Process | late endosome to lysosome transport | |
Biological Process | macroautophagy | |
Biological Process | protein targeting to vacuole | |
Biological Process | regulated exocytosis | |
Biological Process | vesicle-mediated transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVacuolar protein sorting-associated protein 41 homolog
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5KU39
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Peripheral membrane protein
Late endosome membrane ; Peripheral membrane protein
Early endosome membrane ; Peripheral membrane protein
Lysosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000253020 | 1-853 | Vacuolar protein sorting-associated protein 41 homolog | |||
Sequence: MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICSAKNRGPGSAILEMKK |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41. Interacts with RILP, MON1B. Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes. In vitro can self-assemble into a lattice. Associates with adapter protein complex 3 (AP-3) and clathrin:AP-3 complexes. Interacts with STX17; this interaction is increased in the absence of TMEM39A. Interacts with ARL8B and PLEKHM1; the interaction mediates the recruitment of the HOPS complex to lysosomes. Interacts with RAB7, RAB2A and RAB2B (PubMed:28063257).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Acidic residues | ||||
Sequence: MAEAEEQETESLEESTDESEEESEE | ||||||
Region | 1-32 | Disordered | ||||
Sequence: MAEAEEQETESLEESTDESEEESEEEPKLKYE | ||||||
Region | 1-539 | Interaction with ARL8B | ||||
Sequence: MAEAEEQETESLEESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHETFDCPIKIIAVHPQFVRSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQRISNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEVSEKTEREYCARPRLDIIQPLPETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQRNIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVF | ||||||
Repeat | 567-711 | CHCR | ||||
Sequence: VDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITG | ||||||
Zinc finger | 790-838 | RING-type; atypical | ||||
Sequence: CESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICS |
Sequence similarities
Belongs to the VPS41 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length853
- Mass (Da)98,602
- Last updated2005-02-15 v1
- ChecksumA4D54AA7C5D0F2DD
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Acidic residues | ||||
Sequence: MAEAEEQETESLEESTDESEEESEE | ||||||
Sequence conflict | 16 | in Ref. 3; BAE37664 | ||||
Sequence: T → K | ||||||
Sequence conflict | 190 | in Ref. 3; BAC34707 | ||||
Sequence: G → C | ||||||
Sequence conflict | 401 | in Ref. 2; AAN73032 | ||||
Sequence: V → L | ||||||
Sequence conflict | 427-428 | in Ref. 2; AAN73032 | ||||
Sequence: LW → HR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB028843 EMBL· GenBank· DDBJ | BAD88410.1 EMBL· GenBank· DDBJ | mRNA | ||
AF327407 EMBL· GenBank· DDBJ | AAN73032.1 EMBL· GenBank· DDBJ | mRNA | ||
AK051658 EMBL· GenBank· DDBJ | BAC34707.1 EMBL· GenBank· DDBJ | mRNA | ||
AK164177 EMBL· GenBank· DDBJ | BAE37664.1 EMBL· GenBank· DDBJ | mRNA | ||
BC023243 EMBL· GenBank· DDBJ | AAH23243.1 EMBL· GenBank· DDBJ | mRNA | ||
BC049916 EMBL· GenBank· DDBJ | AAH49916.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119362 EMBL· GenBank· DDBJ | AAI19363.1 EMBL· GenBank· DDBJ | mRNA | ||
BC125299 EMBL· GenBank· DDBJ | AAI25300.1 EMBL· GenBank· DDBJ | mRNA |