Q5JRY3 · Q5JRY3_HUMAN

  • Protein
    Transcription factor 7 like 2
  • Gene
    TCF7L2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Features

Showing features for dna binding.

115720406080100120140
TypeIDPosition(s)Description
DNA binding30-98HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Transcription factor 7 like 2

Gene names

    • Name
      TCF7L2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q5JRY3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

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The viewer provides 515 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-32Disordered
Compositional bias13-31Basic and acidic residues
Domain30-98HMG box
Region97-124Disordered

Sequence similarities

Belongs to the TCF/LEF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    157
  • Mass (Da)
    18,297
  • Last updated
    2016-10-05 v2
  • Checksum
    CB00A6CED4938D18
QESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCRARFGLDQQNNWCGPCRCKYSKEVSGTVRA

Computationally mapped potential isoform sequences

There are 14 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9NQB0TF7L2_HUMANTCF7L2619
H0YEE5H0YEE5_HUMANTCF7L2108
Q5JRY4Q5JRY4_HUMANTCF7L2299
A0A1B0GU84A0A1B0GU84_HUMANTCF7L260
A0A1B0GVE1A0A1B0GVE1_HUMANTCF7L2313
A0A0D9SGH8A0A0D9SGH8_HUMANTCF7L2584
A0A0A0MTL7A0A0A0MTL7_HUMANTCF7L2408
Q5VVR5Q5VVR5_HUMANTCF7L2222
Q5VVR7Q5VVR7_HUMANTCF7L2455
Q5VVR8Q5VVR8_HUMANTCF7L2282
C6ZRJ7C6ZRJ7_HUMANTCF7L2476
C6ZRK5C6ZRK5_HUMANTCF7L2579
A0A994J711A0A994J711_HUMANTCF7L2459
A0A994J4F0A0A994J4F0_HUMANTCF7L2291

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias13-31Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL135792
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL158212
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL445486
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL451084
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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