Q5JRY3 · Q5JRY3_HUMAN
- ProteinTranscription factor 7 like 2
- GeneTCF7L2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids157 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 30-98 | HMG box | ||||
Sequence: IKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ5JRY3
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 515 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-32 | Disordered | ||||
Sequence: QESSQSDVGSLHSSKHQDSKKEEEKKKPHIKK | ||||||
Compositional bias | 13-31 | Basic and acidic residues | ||||
Sequence: SSKHQDSKKEEEKKKPHIK | ||||||
Domain | 30-98 | HMG box | ||||
Sequence: IKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWS | ||||||
Region | 97-124 | Disordered | ||||
Sequence: WSARDNYGKKKKRKRDKQPGETNDLSAP |
Sequence similarities
Belongs to the TCF/LEF family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length157
- Mass (Da)18,297
- Last updated2016-10-05 v2
- ChecksumCB00A6CED4938D18
Computationally mapped potential isoform sequences
There are 14 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9NQB0 | TF7L2_HUMAN | TCF7L2 | 619 | ||
H0YEE5 | H0YEE5_HUMAN | TCF7L2 | 108 | ||
Q5JRY4 | Q5JRY4_HUMAN | TCF7L2 | 299 | ||
A0A1B0GU84 | A0A1B0GU84_HUMAN | TCF7L2 | 60 | ||
A0A1B0GVE1 | A0A1B0GVE1_HUMAN | TCF7L2 | 313 | ||
A0A0D9SGH8 | A0A0D9SGH8_HUMAN | TCF7L2 | 584 | ||
A0A0A0MTL7 | A0A0A0MTL7_HUMAN | TCF7L2 | 408 | ||
Q5VVR5 | Q5VVR5_HUMAN | TCF7L2 | 222 | ||
Q5VVR7 | Q5VVR7_HUMAN | TCF7L2 | 455 | ||
Q5VVR8 | Q5VVR8_HUMAN | TCF7L2 | 282 | ||
C6ZRJ7 | C6ZRJ7_HUMAN | TCF7L2 | 476 | ||
C6ZRK5 | C6ZRK5_HUMAN | TCF7L2 | 579 | ||
A0A994J711 | A0A994J711_HUMAN | TCF7L2 | 459 | ||
A0A994J4F0 | A0A994J4F0_HUMAN | TCF7L2 | 291 |
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Q | ||||||
Compositional bias | 13-31 | Basic and acidic residues | ||||
Sequence: SSKHQDSKKEEEKKKPHIK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL135792 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL158212 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL445486 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL451084 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |