Q5JP69 · Q5JP69_HUMAN

  • Protein
    Complement C2
  • Gene
    C2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
    EC:3.4.21.43 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1752100200300400500600700
TypeIDPosition(s)Description
Binding site262Mg2+ (UniProtKB | ChEBI)
Binding site264Mg2+ (UniProtKB | ChEBI)
Binding site337Mg2+ (UniProtKB | ChEBI)
Active site507Charge relay system
Active site507Proton donor/acceptor
Active site561Charge relay system
Active site679Charge relay system
Active site679Nucleophile, Proton donor/acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentclassical-complement-pathway C3/C5 convertase complex
Cellular Componentextracellular exosome
Molecular Functionmetal ion binding
Molecular Functionserine-type endopeptidase activity
Biological Processcomplement activation, classical pathway
Biological Processinnate immune response
Biological Processproteolysis
Biological Processresponse to lipopolysaccharide
Biological Processresponse to nutrient
Biological Processresponse to thyroid hormone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Complement C2
  • EC number
  • Alternative names
    • C3/C5 convertase

Gene names

    • Name
      C2
    • ORF names
      hCG_43694

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q5JP69

Organism-specific databases

Disease & Variants

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501509792121-752Complement C2
Disulfide bond117↔144
Disulfide bond177↔204
Glycosylation332N-acetyl-D-glucosamine 1
Glycosylation333N-acetyl-D-glucosamine 1
Glycosylation333N-linked (GlcNAc...) asparagine
Disulfide bond463↔581
Disulfide bond492↔508
Disulfide bond584↔600
Glycosylation621N-acetyl-D-glucosamine 2
Glycosylation621N-linked (GlcNAc...) asparagine
Disulfide bond638↔665
Disulfide bond675↔705
Glycosylation712N-acetyl-D-glucosamine 2

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-86Sushi
Domain87-146Sushi
Domain149-206Sushi
Domain254-452VWFA
Domain464-744Peptidase S1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    83,268
  • Last updated
    2005-05-10 v1
  • Checksum
    5A96A13E700CF444
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY500771
EMBL· GenBank· DDBJ
AQY77241.1
EMBL· GenBank· DDBJ
Genomic DNA
KY500774
EMBL· GenBank· DDBJ
AQY77244.1
EMBL· GenBank· DDBJ
Genomic DNA
KY500776
EMBL· GenBank· DDBJ
AQY77246.1
EMBL· GenBank· DDBJ
Genomic DNA
AK312581
EMBL· GenBank· DDBJ
BAG35475.1
EMBL· GenBank· DDBJ
mRNA
CH471081
EMBL· GenBank· DDBJ
EAX03549.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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