Knockdown of Eps15 suppresses the internalization of GluA1 but not the mutant GluA1 that lacks ubiquitination sites indicating a role of Eps15 for the internalization of ubiquitinated AMPARs
distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S)
Nedd4-mediated ubiquitination of Cx43 is required to recruit Eps15 through its ubiquitin-interacting motif and targets ubiquitinated Cx43 to the endocytic pathway.
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