Q5ILI9 · Q5ILI9_HETPA
- Proteincytochrome-c oxidase
- Genecox1/2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids778 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Biological Process | aerobic respiration | |
Biological Process | electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecytochrome-c oxidase
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Acytosteliales > Acytosteliaceae > Heterostelium
Accessions
- Primary accessionQ5ILI9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-56 | Helical | ||||
Sequence: LYLIFSILAGIIGTLLSLII | ||||||
Transmembrane | 76-101 | Helical | ||||
Sequence: IITSHGLIMIFFMVMPAMLGGFGNWF | ||||||
Transmembrane | 121-147 | Helical | ||||
Sequence: FWLLVVSFILLLTSSFLGIGAGTGWTL | ||||||
Transmembrane | 167-190 | Helical | ||||
Sequence: LSLHIAGASSLLGAINFVTTIMNM | ||||||
Transmembrane | 202-229 | Helical | ||||
Sequence: LFVWSVLITAILLILSLPVLAGGLTMLI | ||||||
Transmembrane | 262-280 | Helical | ||||
Sequence: VYILILPGFGLISIILAKY | ||||||
Transmembrane | 292-309 | Helical | ||||
Sequence: IAAMLAIGALGFIVWAHH | ||||||
Transmembrane | 321-343 | Helical | ||||
Sequence: AYFTSATMIIAIPTGIKIFSWLA | ||||||
Transmembrane | 355-375 | Helical | ||||
Sequence: ASLFALGFLILFTIGGLTGII | ||||||
Transmembrane | 395-415 | Helical | ||||
Sequence: FHYVLSMGAVFAIFAAYYFFF | ||||||
Transmembrane | 436-457 | Helical | ||||
Sequence: IHFWTMFIGVNVTFFPMHFLGL | ||||||
Transmembrane | 477-501 | Helical | ||||
Sequence: VASYGSLITAIGLLFFFANVFIAYI | ||||||
Transmembrane | 521-540 | Helical | ||||
Sequence: VLKSVLGLISILDISRAGQI | ||||||
Transmembrane | 560-580 | Helical | ||||
Sequence: IFFYLIIVSVFIGWVFIRILW | ||||||
Transmembrane | 614-638 | Helical | ||||
Sequence: ICWTLIPTIILYVIAIPSFTLLYAM |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-500 | Cytochrome oxidase subunit I profile | ||||
Sequence: WIFTVDHKLIGQLYLIFSILAGIIGTLLSLIIRLELSTGTMLDGDSQLFNVIITSHGLIMIFFMVMPAMLGGFGNWFVPIMIGAPDMAFPRLNNISFWLLVVSFILLLTSSFLGIGAGTGWTLYPPLSTMEYHPGVSVDVGILSLHIAGASSLLGAINFVTTIMNMKIAGLKYRKMSLFVWSVLITAILLILSLPVLAGGLTMLITDRNFETTFFDPIGGGDPILYQHLFWFFGHPEVYILILPGFGLISIILAKYSQKGIFGVKGMIAAMLAIGALGFIVWAHHMYTVGMDVDTRAYFTSATMIIAIPTGIKIFSWLATIWGGYIRITTASLFALGFLILFTIGGLTGIILSNGGLDISLHDTYYVVAHFHYVLSMGAVFAIFAAYYFFFSIINSTKAFGIVHYNEQLGRIHFWTMFIGVNVTFFPMHFLGLAGMPRRISDYPDAFVYWNLVASYGSLITAIGLLFFFANVFIAY | ||||||
Domain | 534-642 | Cytochrome oxidase subunit II transmembrane region profile | ||||
Sequence: ISRAGQIGFQDPATPIMEGIIDLHNFIFFYLIIVSVFIGWVFIRILWRFSYKWRYPEKGDMKIFSQFLVYNKIAHGTAIEICWTLIPTIILYVIAIPSFTLLYAMDEIL | ||||||
Domain | 643-778 | Cytochrome oxidase subunit II copper A binding | ||||
Sequence: TPTITIKIIGHQWYWSYEYSDDLNKQIEFDSYMVYEADLQEGQLRLLEVDNPMIVPIKTHIRLIITSEDVLHSWTVPSFGIKVDAVPGRLNQIGLYVKRPGVFYGQCSELCGVDHGFMPIKVKAVSIGKYLKTLYE |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length778
- Mass (Da)87,551
- Last updated2005-02-15 v1
- ChecksumE601A76E896AB3ED
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY700145 EMBL· GenBank· DDBJ | AAU00621.1 EMBL· GenBank· DDBJ | Genomic DNA |