Q5IGR6 · EXT1C_DANRE

Function

function

Glycosyltransferase required for the biosynthesis of heparan-sulfate.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Protein modification; protein glycosylation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site432UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site540UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site556UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site557UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site558Mn2+ (UniProtKB | ChEBI); catalytic
Binding site558UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site644UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Active site645
Binding site645UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site692UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi apparatus
Molecular Functionacetylglucosaminyltransferase activity
Molecular Functionglucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
Molecular Functionglucuronosyltransferase activity
Molecular Functionmetal ion binding
Molecular FunctionN-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
Biological Processheparan sulfate proteoglycan biosynthetic process
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT47Glycosyltransferase Family 47
    • GT64Glycosyltransferase Family 64

Names & Taxonomy

Protein names

  • Recommended name
    Exostosin-1c
  • EC number
  • Alternative names
    • Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1c
    • Multiple exostoses protein 1 homolog c

Gene names

    • Name
      ext1c

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q5IGR6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-6Cytoplasmic
Transmembrane7-27Helical; Signal-anchor for type II membrane protein
Topological domain28-737Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001496611-737Exostosin-1c
Glycosylation194N-linked (GlcNAc...) asparagine
Glycosylation322N-linked (GlcNAc...) asparagine
Disulfide bond643↔695

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed zygotically. First detected at the beginning of somatogenesis. At the 16-somite stage, restricted to posterior adaxial cells and, in the anterior, to cells adjacent to the neural tube and to ventromedial reigons of the somites. At 24 hours-post-fertilization (hpf), expressed in the ventral rhombomeres, telencephalon and olfactory bulbs. At 48 hpf, expressed in the brain, retina and fin buds.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    737
  • Mass (Da)
    85,389
  • Last updated
    2005-02-15 v1
  • Checksum
    349EB644FB7AADB4
MQARKKYVLLGLCTCCWILLYYWAGLQERLLGLITHRRGEVPRPWPDWLDRALLPNFAEQLDLQNGGGPGDSPRQRKQAWSSIYKDSRCRMDTCFDFGRCQTQSGFRVYIYPPEKGERVSEGYRKILTSVSESRYYTSDPREACLFVLGIDTLDRDQLSQQFVPNVDERIRGYPLWNDGRNHVIFNLYSGTWPNYTEDLGFNVGQAILAKASLNTEHFRPGFDISIPLFSKEHPQKGGKRGWLVRNSVPPRRKYLLMFKGKRYLTGIGSDTRNALHHIHNGKDIVSLTTCRHGKDWEKHKDARCDHDNQEYERFDYQELLHNSTFCLVPRGRRLGSFRFLESLQAACIPVLLSNGWELPFSDVIQWNQAVVEGDERLLLQVPSTVRAVGIDRVLALRQQTQTLWDAYFSSVDKIVLTTLEIIKDRVYSHISRNKLMWNALPGGLLVLPEFSTHLAHYPFYYLHLGISPGLEFTAVIHATSPLVSQSQPIMKLLQVVSKSKYCSQIIILWNSEKSPPQRSKWPPMPVPLTVTDGRRKTSSRFLPHAAIETEAVLSLDEDTVLLTSEINFAFHVWRSFPDRIVGYPPRSHFWDPVKKAWGYTSKWTNEYSIILTGAAFYHRYYHHLFSHYLPSSLRALVDHSCNCEDILMNFLVSSVAHLPPVKVAQRKQYKEMPSLQGTKMAPWANPEHFTQRQECVNTFSSWFGYMPLEHSQFRLDPVLFKDHVSVLRKRYKDLERV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q1RLZ5Q1RLZ5_DANREext1c737

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY734457
EMBL· GenBank· DDBJ
AAW29035.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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