Q5ICG5 · Q5ICG5_MOUSE

  • Protein
    Long-chain-fatty-acid--CoA ligase
  • Gene
    Acsl6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.15 (UniProtKB | ENZYME | Rhea)
  • (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA
    This reaction proceeds in the forward direction.
  • a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.3 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid-CoA ligase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Long-chain-fatty-acid--CoA ligase
  • EC number
  • Alternative names
    • Acyl-CoA synthetase
    • Long-chain acyl-CoA synthetase

Gene names

    • Name
      Acsl6

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5ICG5

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type III membrane protein
Membrane
; Single-pass type III membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass type III membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-44Helical

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain117-520AMP-dependent synthetase/ligase

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    77,970
  • Last updated
    2006-09-19 v1
  • Checksum
    F4B43D9114732C60
MQTQEILRILRLPELSDLGQFFRSLSATTLVSVGALAAVLAYWLTHRPKALQPPCNLLKQSEEVEDGGGARRSVIGGCTQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFVGVFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSISYIINTADICTVIVDKPHKATLLLEHVERKETPGLKLVILMEPFEDALRERGKKCGVDIKSMQAIEDCGRENHHAPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHFSYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEFAAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTCKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKKGIEGTYQELCMKKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYLVSV

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q91WC3ACSL6_MOUSEAcsl6697
B0QZJ6B0QZJ6_MOUSEAcsl6192
E9Q7Y2E9Q7Y2_MOUSEAcsl6365
Q8R1X1Q8R1X1_MOUSEAcsl6722
Q8C028Q8C028_MOUSEAcsl6359
B1ARG5B1ARG5_MOUSEAcsl6139
F6WYN6F6WYN6_MOUSEAcsl6126
Q5F2C5Q5F2C5_MOUSEAcsl6622
Q8BYJ0Q8BYJ0_MOUSEAcsl6424

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY786360
EMBL· GenBank· DDBJ
AAW33883.1
EMBL· GenBank· DDBJ
mRNA
AY786362
EMBL· GenBank· DDBJ
AAW33885.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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