Q5IBH7 · SPDYA_MOUSE

  • Protein
    Speedy protein A
  • Gene
    Spdya
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625).
Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentnuclear envelope
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentXY body
Molecular Functionprotein kinase activator activity
Molecular Functionprotein kinase binding
Biological ProcessDNA damage response
Biological Processestablishment of protein localization to telomere
Biological ProcessG1/S transition of mitotic cell cycle
Biological Processmale meiotic nuclear division
Biological Processmeiotic attachment of telomere to nuclear envelope
Biological Processoogenesis
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Processspermatogenesis
Biological Processtelomere capping

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Speedy protein A
  • Alternative names
    • Protein expressed in male leptotene and zygotene spermatocytes 465 (MLZ-465)
    • Rapid inducer of G2/M progression in oocytes A (RINGO A; mSpy/Ringo A)
    • Speedy-1 (Spy1)

Gene names

    • Name
      Spdya
    • Synonyms
      Spdy1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5IBH7
  • Secondary accessions
    • B8JJC0
    • Q5IBH8
    • Q8C5T5

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis89Abolishes interaction with CDK2.
Mutagenesis102Abolishes interaction with CDK2.
Mutagenesis106Abolishes interaction with CDK2.
Mutagenesis107Abolishes interaction with CDK2.
Mutagenesis133-135No effect on CDK2-binding.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002341131-310Speedy protein A
Modified residue221Phosphoserine
Modified residue223Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at a high level in testis. Also expressed in the adult ovary and in immature oocytes.

Gene expression databases

Interaction

Subunit

Interacts with CDK1, CDK2 and CDKN1B/KIP1 (PubMed:15611625).
Identified in a complex with CDK2 and CDKN1B/KIP1, where it interacts primarily with CDK2 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region67-199Speedy/Ringo box; Required for CDK-binding
Region241-310Disordered
Compositional bias273-289Polar residues
Compositional bias290-310Basic and acidic residues

Domain

The C-terminus is required for CDK2-activation, but not CDK2-binding.

Sequence similarities

Belongs to the Speedy/Ringo family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q5IBH7-2

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    2
  • Synonyms
    A2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    310
  • Mass (Da)
    36,115
  • Last updated
    2011-07-27 v2
  • Checksum
    10F372690FF03826
MRHNQMYCETPPTVTIHVKSGSNRSHQTRKPISLKRPILKDSWEASENNAQNNKSKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVHLPRGPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDTGELMEKDSQELHSAFSVDTAGDPPHTYSQVANDHQSNKENETNFVKKNKSVEWFAESEE

Q5IBH7-1

  • Name
    1
  • Synonyms
    A1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B8JJB9B8JJB9_MOUSESpdya309

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict258in Ref. 1; AAW32476/AAW32477
Compositional bias273-289Polar residues
Alternative sequenceVSP_052029281-283in isoform 1
Alternative sequenceVSP_052030284-310in isoform 1
Compositional bias290-310Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY820306
EMBL· GenBank· DDBJ
AAW32476.1
EMBL· GenBank· DDBJ
mRNA
AY820307
EMBL· GenBank· DDBJ
AAW32477.1
EMBL· GenBank· DDBJ
mRNA
AK077138
EMBL· GenBank· DDBJ
BAC36637.1
EMBL· GenBank· DDBJ
mRNA
CT010429
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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