Q5I0E5 · CLD18_RAT

Function

function

Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity).
Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463).
Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity).
Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity).
Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity).

Isoform A2.1

Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbicellular tight junction
Cellular Componentcell-cell junction
Cellular Componentplasma membrane
Cellular Componenttight junction
Molecular Functionstructural molecule activity
Biological Processbicellular tight junction assembly
Biological Processcell adhesion
Biological Processcellular response to estrogen stimulus
Biological Processdigestive tract development
Biological Processepithelial cell proliferation
Biological Processepithelial fluid transport
Biological Processlung alveolus development
Biological Processnegative regulation of bone resorption
Biological Processnegative regulation of osteoclast development
Biological Processnegative regulation of protein localization to nucleus
Biological Processnegative regulation of tumor necrosis factor-mediated signaling pathway
Biological Processorgan growth
Biological Processprotein localization to nucleus
Biological Processresponse to ethanol
Biological Processtight junction assembly
Biological Processtight junction organization

Names & Taxonomy

Protein names

  • Recommended name
    Claudin-18

Gene names

    • Name
      Cldn18

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5I0E5
  • Secondary accessions
    • A0A8I6A5Z5
    • F1LNR6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-6Cytoplasmic
Transmembrane7-27Helical
Topological domain28-80Extracellular
Transmembrane81-101Helical
Topological domain102-122Cytoplasmic
Transmembrane123-143Helical
Topological domain144-173Extracellular
Transmembrane174-194Helical
Topological domain195-261Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001447801-261Claudin-18
Modified residue214Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the lung (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with TJP2/ZO-2 (By similarity).
Interacts with TJP1/ZO-1 (By similarity).
Interacts with YAP1 (phosphorylated); the interaction sequesters YAP1 away from the nucleus and thereby restricts transcription of YAP1 target genes (By similarity).
Interacts with CLDN19

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region195-261Required for role in regulation of RANKL-induced osteoclast differentiation
Region242-261Disordered

Sequence similarities

Belongs to the claudin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q5I0E5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    A1.1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    261
  • Mass (Da)
    27,922
  • Last updated
    2005-02-15 v1
  • Checksum
    A40E17FCBCC65D51
MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGIMFIISGVCAIIGVSVFANMLVTNFWMSTANMYSGMGGMVQTVQTRYTFGAALFVGWIAGGLTLIGGVMMCIACRGLTPDDRNFKAVSYHASGQNVAYKPGGFKASTGFGSNARNKKIYDGGARTEDDEQSHPTKYDYV

Q5I0E5-2

  • Name
    A2.1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-69: MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVQQSSGFTECRPYFTI → MSVTACQGLGFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5Y8A8A0A8I5Y8A8_RATCldn18252

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0617991-69in isoform A2.1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473954
EMBL· GenBank· DDBJ
EDL77432.1
EMBL· GenBank· DDBJ
Genomic DNA
CH473954
EMBL· GenBank· DDBJ
EDL77433.1
EMBL· GenBank· DDBJ
Genomic DNA
BC088427
EMBL· GenBank· DDBJ
AAH88427.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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