Q5I0D6 · NOSTN_RAT

Function

function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentcytoskeleton
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionDNA binding
Biological Processactin filament organization
Biological Processcell migration
Biological Processendocytosis
Biological Processnegative regulation of DNA-templated transcription
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nostrin
  • Alternative names
    • BM247
    • Nitric oxide synthase trafficker
    • eNOS-trafficking inducer

Gene names

    • Name
      Nostrin

Organism names

  • Taxonomic identifier
  • Strain
    • SHRSP
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5I0D6
  • Secondary accessions
    • Q923J7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasmic vesicle
Cytoplasm
Nucleus
Note: Enriched in selected actin structures.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002890911-502Nostrin
Modified residue114Phosphoserine
Modified residue479Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Over-expressed in brain microcapillaries from spontaneously hypertensive rats.

Gene expression databases

Interaction

Subunit

Homotrimer. Interacts with DAB2. Interacts with NOS3, WASL and CAV1 (By similarity).
Interacts (via SH3 domain) with DNM2; this interaction allows the recruitment of NOS3 to dynamin-positive structures (PubMed:16234328).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain1-260F-BAR
Coiled coil160-230
Domain292-372REM-1
Coiled coil305-335
Region413-437Disordered
Compositional bias420-437Polar residues
Domain438-497SH3

Domain

The SH3 domain mediates interaction with NOS3, DNM2 and WASL.
The F-BAR domain is necessary for membrane targeting.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    502
  • Mass (Da)
    57,352
  • Last updated
    2005-02-15 v1
  • Checksum
    DE8944D1939CCC4C
MRDPLTDCSYNKVYKSLKEFAQNGDNFCKQITSVLQQRANLEISYAKGLQKLAVKLSKALQSTKKNCLSTAWAWASESMKSAADLHQKLGKAIELEAIKPTHQVLSMQEKKRKSLDNEVEKSANLVINNWNQQIKAKKKLMMSTKKHEALFHLIESSKQSMTQKEKQKLLNKLKKSTEKLEKEDESYYQKNMAGYSTRLKWESTLEKCYKSMLELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKVDVEKDIQALMEETAVLSLENKSELLLADYFEEDPKNPMDKERRKSLIKPKLWRLQKDIEKASRDKEGLEQKLKALASSASFSDAKSQKDAETLMDENSLKLDLLQANSYKLSTVLADLEQRPKPCHPCSNCIFKWKEKEHSHSYVKISRPLLTKRLEKAESKAPAGEQNNPSSSRPGSSVSQGNNQLCKALYTFQARQDDELNLEKGDIVTIHEKKEEGWWFGSLNGKKGHFPAAYVEELPPKAGQA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AC89A0A8I6AC89_RATNostrin530

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias420-437Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC088446
EMBL· GenBank· DDBJ
AAH88446.1
EMBL· GenBank· DDBJ
mRNA
AY032855
EMBL· GenBank· DDBJ
AAK64518.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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