Q5I050 · NUP1B_XENLA

Function

function

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of nubp1 and two labile, bridging clusters between subunits of the nubp1-nubp2 heterotetramer.

Features

Showing features for binding site.

131520406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site12[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site26[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site29[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site35[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site66-73ATP (UniProtKB | ChEBI)
Binding site239[4Fe-4S] cluster 2 (UniProtKB | ChEBI); ligand shared with heterodimeric partner
Binding site242[4Fe-4S] cluster 2 (UniProtKB | ChEBI); ligand shared with heterodimeric partner

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionATP binding
Molecular FunctionATP-dependent FeS chaperone activity
Molecular Functioniron-sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processiron-sulfur cluster assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic Fe-S cluster assembly factor nubp1-B
  • Alternative names
    • Nucleotide-binding protein 1-B
      (NBP 1-B
      )

Gene names

    • Name
      nubp1-B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q5I050

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003825941-315Cytosolic Fe-S cluster assembly factor nubp1-B

Expression

Gene expression databases

    • 496286Expressed in testis and 19 other cell types or tissues

Interaction

Subunit

Heterotetramer of 2 nubp1 and 2 nubp2 chains.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    33,704
  • Last updated
    2005-02-15 v1
  • Checksum
    4FF321470DE5E9E1
MADIPENAPQHCPGTGSTEAGKSSACQGCPNQSICASAATSAPDPAIEEIKEKMSLVKHKILVLSGKGGVGKSTFSAHLAHGLAQDEGKEVALLDVDICGPSIPRMMGLEGEQVHQSGSGWSPVYVEDNLAVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGEVDYLIVDTPPGTSDEHLSVVQYLSAAGIDGAVIVTTPQEVSLQDVRKEINFCRKVKLPIIGVVENMSGFICPKCENESQIFPPTTGGAEKMCTDLNVSLLGKVPLDPNIGKSCDTGKSFFTEIPDSPATLSYRIIIQRIQDYCEKKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC088708
EMBL· GenBank· DDBJ
AAH88708.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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