Q5HZ60 · MCES2_ARATH

Function

function

mRNA capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity).

Catalytic activity

Features

Showing features for binding site, site.

135450100150200250300350
Type
IDPosition(s)Description
Binding site21S-adenosyl-L-methionine (UniProtKB | ChEBI)
Site48mRNA cap binding
Binding site61S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site88-89S-adenosyl-L-methionine (UniProtKB | ChEBI)
Site278mRNA cap binding

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mRNA cap guanine-N(7) methyltransferase 2
  • EC number
  • Alternative names
    • mRNA (guanine-N(7))-methyltransferase 2
    • mRNA cap methyltransferase 2

Gene names

    • ORF names
      F4F15.320, T25B15.21
    • Ordered locus names
      At3g52210

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q5HZ60
  • Secondary accessions
    • Q67Y41
    • Q682G2
    • Q9SUY4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002601521-354mRNA cap guanine-N7 methyltransferase 2

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-286mRNA cap 0 methyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q5HZ60-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    354
  • Mass (Da)
    39,889
  • Last updated
    2005-02-15 v1
  • Checksum
    D6950C807B3966D5
MSGFVVSKPEQSHHRLFDFAKTAIINIFAHPYATVCELYCGGAPETDKWEAAPIGHYIGIDTSSGISSVREAWESQRKNYDVEFFEADPSKDDFEIQLQKKLEQADLVSCWRHLQLCFETEESARRLLTNVACLLKPGGYFFGITPDSSTIWAKYQKNVEAYHNRSGAKPNVFPNYIRSESYMITFELEEEKFPLFGKRYQLKFSGDNASEDHCLVHFPSLIRLAREAGLEFVEIQSLTDFYDDNRAQFASLLMNAGPNFVDPRGKLLPRAFDLLGLYATFIFQKPDPDIEPPLTTPIPFESSNNHDERELPVITVITDASAPAEDPSQGLGKIVEQKGILGPGPADLRFSEAI

Q5HZ60-2

  • Name
    2
  • Note
    May be due to a competing acceptor splice site.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q5HZ60-3

  • Name
    3
  • Note
    May be due to a competing acceptor splice site.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence CAB41341.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_02157660in isoform 2
Sequence conflict83in Ref. 3; BAD43168
Alternative sequenceVSP_021577246-250in isoform 3
Alternative sequenceVSP_021578251-354in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL049711
EMBL· GenBank· DDBJ
CAB41341.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL132972
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002686
EMBL· GenBank· DDBJ
AEE78914.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE78915.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE78916.1
EMBL· GenBank· DDBJ
Genomic DNA
AK175405
EMBL· GenBank· DDBJ
BAD43168.1
EMBL· GenBank· DDBJ
mRNA
AK176609
EMBL· GenBank· DDBJ
BAD44372.1
EMBL· GenBank· DDBJ
mRNA
AK176627
EMBL· GenBank· DDBJ
BAD44390.1
EMBL· GenBank· DDBJ
mRNA
BT020464
EMBL· GenBank· DDBJ
AAW38965.1
EMBL· GenBank· DDBJ
mRNA
BT020571
EMBL· GenBank· DDBJ
AAW78590.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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