Q5HG20 · DCDA_STAAC
- ProteinDiaminopimelate decarboxylase
- GenelysA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids421 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine (By similarity).
Plays a role in beta-lactam antibiotic resistance
Plays a role in beta-lactam antibiotic resistance
Catalytic activity
- meso-2,6-diaminoheptanedioate + H+ = L-lysine + CO2
Cofactor
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 237 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 279-282 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 282 | substrate | |||
Binding site | 319 | substrate | |||
Binding site | 323 | substrate | |||
Active site | 349 | Proton donor | |||
Binding site | 350 | substrate | |||
Binding site | 379 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | |||
Binding site | 379 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | diaminopimelate decarboxylase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate decarboxylase
- EC number
- Short namesDAP decarboxylase; DAPDC
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ5HG20
Proteomes
Phenotypes & Variants
Disruption phenotype
Disruption of this gene does not affect growth in rich organic media but reduces the level of methicillin resistance by nearly 100-fold.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000411131 | 1-421 | Diaminopimelate decarboxylase | ||
Modified residue | 62 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length421
- Mass (Da)47,035
- Last updated2005-02-15 v1
- MD5 Checksum8E84C287E7FE07D2C1F86A2862A3E12E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000046 EMBL· GenBank· DDBJ | AAW38180.1 EMBL· GenBank· DDBJ | Genomic DNA |