Q5HG20 · DCDA_STAAC

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine (By similarity).
Plays a role in beta-lactam antibiotic resistance

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

142150100150200250300350400
Type
IDPosition(s)Description
Binding site237pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site279-282pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site282substrate
Binding site319substrate
Binding site323substrate
Active site349Proton donor
Binding site350substrate
Binding site379pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site379substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase; DAPDC

Gene names

    • Name
      lysA
    • Ordered locus names
      SACOL1435

Organism names

Accessions

  • Primary accession
    Q5HG20

Proteomes

Phenotypes & Variants

Disruption phenotype

Disruption of this gene does not affect growth in rich organic media but reduces the level of methicillin resistance by nearly 100-fold.

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00004111311-421Diaminopimelate decarboxylase
Modified residue62N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    421
  • Mass (Da)
    47,035
  • Last updated
    2005-02-15 v1
  • MD5 Checksum
    8E84C287E7FE07D2C1F86A2862A3E12E
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQLDVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFIQTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGIKYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRTALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDGKAREVIKRQSLRQLIINDTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000046
EMBL· GenBank· DDBJ
AAW38180.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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