Q5HAF8 · PYRH_EHRRW

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

124420406080100120140160180200220240
TypeIDPosition(s)Description
Binding site17-20ATP (UniProtKB | ChEBI)
Binding site59UMP (UniProtKB | ChEBI)
Binding site60ATP (UniProtKB | ChEBI)
Binding site64ATP (UniProtKB | ChEBI)
Binding site80UMP (UniProtKB | ChEBI)
Binding site141-148UMP (UniProtKB | ChEBI)
Binding site168ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)
Binding site177ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • Ordered locus names
      Erum7240, ERWE_CDS_07620

Organism names

Accessions

  • Primary accession
    Q5HAF8
  • Secondary accessions
    • Q5FDJ3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003238441-244Uridylate kinase

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region25-30Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    244
  • Mass (Da)
    26,369
  • Last updated
    2005-02-15 v1
  • Checksum
    77B61DF9A5DFE5D1
MSENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGGNIFRGASASAPFGFERASNDYIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETYIRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMGCNVIFKGTQVDGVYSADPKKVADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYTTIYN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR767821
EMBL· GenBank· DDBJ
CAH58456.1
EMBL· GenBank· DDBJ
Genomic DNA
CR925678
EMBL· GenBank· DDBJ
CAI27256.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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