Q5HAF8 · PYRH_EHRRW
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids244 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-20 | ATP (UniProtKB | ChEBI) | |||
Binding site | 59 | UMP (UniProtKB | ChEBI) | |||
Binding site | 60 | ATP (UniProtKB | ChEBI) | |||
Binding site | 64 | ATP (UniProtKB | ChEBI) | |||
Binding site | 80 | UMP (UniProtKB | ChEBI) | |||
Binding site | 141-148 | UMP (UniProtKB | ChEBI) | |||
Binding site | 168 | ATP (UniProtKB | ChEBI) | |||
Binding site | 169 | ATP (UniProtKB | ChEBI) | |||
Binding site | 174 | ATP (UniProtKB | ChEBI) | |||
Binding site | 177 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Ehrlichia
Accessions
- Primary accessionQ5HAF8
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000323844 | 1-244 | Uridylate kinase | ||
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length244
- Mass (Da)26,369
- Last updated2005-02-15 v1
- Checksum77B61DF9A5DFE5D1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR767821 EMBL· GenBank· DDBJ | CAH58456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR925678 EMBL· GenBank· DDBJ | CAI27256.1 EMBL· GenBank· DDBJ | Genomic DNA |