Q5GH62 · XKR9_MOUSE
- ProteinXK-related protein 9
- GeneXkr9
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
XK-related protein 9, processed form
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987).
Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987).
Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987).
Catalytic activity
XK-related protein 9, processed form
a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
Activity regulation
Activated upon caspase cleavage to generate the XK-related protein 9, processed form (PubMed:25231987).
Does not act prior the onset of apoptosis (PubMed:25231987).
Does not act prior the onset of apoptosis (PubMed:25231987).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 357-358 | Cleavage; by caspase-3, caspase-6 and caspase-7 | ||||
Sequence: DG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | apoptotic process involved in development | |
Biological Process | engulfment of apoptotic cell | |
Biological Process | phosphatidylserine exposure on apoptotic cell surface |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameXK-related protein 9
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5GH62
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 8-28 | Helical | ||||
Sequence: FMMSVLGIIIYVTDLVADIVL | ||||||
Transmembrane | 38-58 | Helical | ||||
Sequence: YVLGVLTLSFVLCGTLIVHCF | ||||||
Transmembrane | 166-186 | Helical | ||||
Sequence: MVIMVSCCAISWSTVDYQIAL | ||||||
Transmembrane | 206-226 | Helical | ||||
Sequence: LFYKLLTLLSWMLSVVLLLFV | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: VALLLLLFLWITGFIWAFINH | ||||||
Transmembrane | 256-276 | Helical | ||||
Sequence: SVSMEFLYRIVVGFILVFTFF | ||||||
Transmembrane | 295-315 | Helical | ||||
Sequence: VLGTLGILTVFWIYPLSIFNS | ||||||
Transmembrane | 318-338 | Helical | ||||
Sequence: FIPISATIVLALLLGIIFLGV |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 354-357 | In 2DA mutant; abolished cleavage by caspase, preventing phospholipid scramblase activity. | ||||
Sequence: DETD → AETA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000453294 | 1-357 | XK-related protein 9, processed form | |||
Sequence: MKYTKCNFMMSVLGIIIYVTDLVADIVLSVRYFHDGQYVLGVLTLSFVLCGTLIVHCFSYSWLKADLEKAGQENERYFLLLHCLQGGVFTRYWFALRTGYHVVFKHSDRKSNFMEEQTDPHKEAIDMATDLSMLRLFETYLEGCPQLILQLYAFLECGQANLSQCMVIMVSCCAISWSTVDYQIALRKSLPDKNLLRGLWPKLMYLFYKLLTLLSWMLSVVLLLFVDVRVALLLLLFLWITGFIWAFINHTQFCNSVSMEFLYRIVVGFILVFTFFNIKGQNTKCPMSCYYTVRVLGTLGILTVFWIYPLSIFNSDYFIPISATIVLALLLGIIFLGVYYGNFHPNRNVEPQLDETD | ||||||
Chain | PRO_0000190797 | 1-373 | XK-related protein 9 | |||
Sequence: MKYTKCNFMMSVLGIIIYVTDLVADIVLSVRYFHDGQYVLGVLTLSFVLCGTLIVHCFSYSWLKADLEKAGQENERYFLLLHCLQGGVFTRYWFALRTGYHVVFKHSDRKSNFMEEQTDPHKEAIDMATDLSMLRLFETYLEGCPQLILQLYAFLECGQANLSQCMVIMVSCCAISWSTVDYQIALRKSLPDKNLLRGLWPKLMYLFYKLLTLLSWMLSVVLLLFVDVRVALLLLLFLWITGFIWAFINHTQFCNSVSMEFLYRIVVGFILVFTFFNIKGQNTKCPMSCYYTVRVLGTLGILTVFWIYPLSIFNSDYFIPISATIVLALLLGIIFLGVYYGNFHPNRNVEPQLDETDGKAPQRDCRIRYFLMD |
Post-translational modification
XK-related protein 9
Undergoes proteolytic processing by caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate the XK-related protein 9, processed form, leading to its activation.
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in the small intestines; weakly expressed in the pancreas, liver, stomach, and large intestines.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length373
- Mass (Da)43,271
- Last updated2005-03-01 v1
- Checksum8F3C976AB36BE067
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY534255 EMBL· GenBank· DDBJ | AAT07104.1 EMBL· GenBank· DDBJ | mRNA | ||
BC147699 EMBL· GenBank· DDBJ | AAI47700.1 EMBL· GenBank· DDBJ | mRNA |