Q5GH62 · XKR9_MOUSE

  • Protein
    XK-related protein 9
  • Gene
    Xkr9
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

XK-related protein 9, processed form

Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987).
Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:25231987).

Catalytic activity

Activity regulation

Activated upon caspase cleavage to generate the XK-related protein 9, processed form (PubMed:25231987).
Does not act prior the onset of apoptosis (PubMed:25231987).

Features

Showing features for site.

137350100150200250300350
TypeIDPosition(s)Description
Site357-358Cleavage; by caspase-3, caspase-6 and caspase-7

GO annotations

AspectTerm
Cellular Componentplasma membrane
Biological Processapoptotic process involved in development
Biological Processengulfment of apoptotic cell
Biological Processphosphatidylserine exposure on apoptotic cell surface

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      Xkr9
    • Synonyms
      Gm1620
      , Xrg9

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5GH62
  • Secondary accessions
    • B2RWB3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane8-28Helical
Transmembrane38-58Helical
Transmembrane166-186Helical
Transmembrane206-226Helical
Transmembrane230-250Helical
Transmembrane256-276Helical
Transmembrane295-315Helical
Transmembrane318-338Helical

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis354-357In 2DA mutant; abolished cleavage by caspase, preventing phospholipid scramblase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004532941-357
ChainPRO_00001907971-373

Post-translational modification

XK-related protein 9

Undergoes proteolytic processing by caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate the XK-related protein 9, processed form, leading to its activation.

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in the small intestines; weakly expressed in the pancreas, liver, stomach, and large intestines.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the XK family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    43,271
  • Last updated
    2005-03-01 v1
  • Checksum
    8F3C976AB36BE067
MKYTKCNFMMSVLGIIIYVTDLVADIVLSVRYFHDGQYVLGVLTLSFVLCGTLIVHCFSYSWLKADLEKAGQENERYFLLLHCLQGGVFTRYWFALRTGYHVVFKHSDRKSNFMEEQTDPHKEAIDMATDLSMLRLFETYLEGCPQLILQLYAFLECGQANLSQCMVIMVSCCAISWSTVDYQIALRKSLPDKNLLRGLWPKLMYLFYKLLTLLSWMLSVVLLLFVDVRVALLLLLFLWITGFIWAFINHTQFCNSVSMEFLYRIVVGFILVFTFFNIKGQNTKCPMSCYYTVRVLGTLGILTVFWIYPLSIFNSDYFIPISATIVLALLLGIIFLGVYYGNFHPNRNVEPQLDETDGKAPQRDCRIRYFLMD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY534255
EMBL· GenBank· DDBJ
AAT07104.1
EMBL· GenBank· DDBJ
mRNA
BC147699
EMBL· GenBank· DDBJ
AAI47700.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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