a substrate of PKCepsilon Ephexin5 whose early-elevated expression in developing neurons may in part explain the mechanism by which PKCepsilon plays seemingly opposing roles that depend on neuronal maturity.
The data of this study support a model in which Ephexin5 serves a dual role in spinogenesis acting both as a brake on overall spine outgrowth and as a necessary component in the site-specific formation of new spines
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