Q5FVW1 · Q5FVW1_XENTR
- ProteinProthrombin
- Genef2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids607 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Thrombin triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 392 | Charge relay system | |||
Active site | 448 | Charge relay system | |||
Active site | 553 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | acute-phase response | |
Biological Process | blood coagulation | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProthrombin
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ5FVW1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5033206171 | 23-607 | Prothrombin | ||
Disulfide bond | 58↔63 | ||||
Disulfide bond | 88↔101 | ||||
Disulfide bond | 108↔184 | ||||
Disulfide bond | 129↔167 | ||||
Disulfide bond | 155↔179 | ||||
Disulfide bond | 208↔285 | ||||
Disulfide bond | 229↔268 | ||||
Disulfide bond | 256↔280 | ||||
Disulfide bond | 322↔468 | Interchain (between light and heavy chains) | |||
Disulfide bond | 377↔393 | ||||
Disulfide bond | 521↔535 | ||||
Disulfide bond | 549↔579 | ||||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 41-87 | Gla | |||
Domain | 107-184 | Kringle | |||
Domain | 207-285 | Kringle | |||
Domain | 350-603 | Peptidase S1 | |||
Sequence similarities
Belongs to the peptidase S1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)69,503
- Last updated2005-03-01 v1
- Checksum681C15339E41947A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC089747 EMBL· GenBank· DDBJ | AAH89747.1 EMBL· GenBank· DDBJ | mRNA |