Q5FVK6 · C2D1B_RAT

  • Protein
    Coiled-coil and C2 domain-containing protein 1B
  • Gene
    Cc2d1b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendosome membrane
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coiled-coil and C2 domain-containing protein 1B
  • Alternative names
    • Five prime repressor element under dual repression-binding protein 2 (FRE under dual repression-binding protein 2; Freud-2)

Gene names

    • Name
      Cc2d1b

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5FVK6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002884281-850Coiled-coil and C2 domain-containing protein 1B
Modified residue585Phosphoserine
Modified residue588Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in epididymal sperm but not in testicular sperm (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with CHMP4B.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, compositional bias, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Region54-73Disordered
Region114-145Disordered
Coiled coil167-213
Region215-277Disordered
Region436-525Disordered
Compositional bias509-525Polar residues
Domain668-807C2

Sequence similarities

Belongs to the CC2D1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q5FVK6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    850
  • Mass (Da)
    93,534
  • Last updated
    2007-05-29 v2
  • Checksum
    2132241D45424146
MPGPRPRKGPKTSGQGAETAKQLGLFVEFNPEDMLLGMDETEDDGDLEAELLALTGETGSTSRKPAPKGRAPLPMAHIEKLAADCMRDVEEEGEEEEGLEDDADLLTELQEVLGVDEETGLVDDSEETSPDLSEEKTRDNTEQPVAPAAFQQALPAAVAQAGGPRGLQALLEERIQNYREAAASAKEAGEAAKARRCERGLKTLESQLATVRKGGKICEDEIPPPVALGKRPPAHQERPSKDSEIDSAGSCAMDPGDLSQPESSLPAVAALPDSDPDPQALLLARQREYKAAALSAKRAGDLDRARELMRIGKRFGTVLEALEKGQPVDLSGMPPAPEDLKALPQASEASAATQVLSPAVEQMQPVMSSDLPATPAAPAEPKTVLDALQQRLNRYREAGIQARASGDERKARMHDRIAKQYQDAIRAHQAGRKVDFAELPVPPGFPPIPGLEPRKDTEEDSVTATLAAAQKLASEDTALVDEDEERDTPAQAPLAKKPAQPLVPSSHLLNEPKASSSKESLSPSVREQVTLLEARKLQYQRAALQAKRRQDLEQAKSHLRVAKSLEAQIIQARAGQPIDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKILLEQHEKCLLFSKQFMHQGNVAETTRFEKLAEDRKKQLEILQLAQAQGLDPPSHHFELKTLQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFEQVFKLNINRNHRGFRRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLEKECEIREIMEVLDGRKPTGGKLEVKVRLREPLSSQDVQMVTENWLVLEPRGL

Q5FVK6-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A5T1A0A8I6A5T1_RATCc2d1b848

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0256641-692in isoform 2
Compositional bias509-525Polar residues

Mass Spectrometry

Molecular mass is 93,476.08 Da. Determined by MALDI.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03040177
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC089922
EMBL· GenBank· DDBJ
AAH89922.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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