Q5FVG2 · E41L5_RAT
- ProteinBand 4.1-like protein 5
- GeneEpb41l5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids731 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBand 4.1-like protein 5
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ5FVG2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000330356 | 1-731 | Band 4.1-like protein 5 | |||
Sequence: MLSFLRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDAKSVITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPTQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKGSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQVKGEVWPCSTGSVHNASAQNNDSQQAWGMKSPVPVTSFSSSGPVLVETENLPQNSAADQHDRKRLPLSIDLLNSPDLLETTIGDVTRPSDTSAPFPAPDDVNVATMSHELEELRADCETLKDDTEKLKQLNTEQNILPSLRPAIDINVNSQEEVVKLTEKCLNNAIESPGLNTVRVPPDFKSNILKAQVEAVHKATREDSLLTHKNASVQDAATNSTVFNENNMPLCKDSLTPVHGTTADSDSVLKDATDELDALLLSLTENLMDHTVTPQVSSSSMITPRWIIPQNSTISNGLAGYGVSLTGTEGCNQKDGFSLISPPAPFLVDAVTSSAPPLPGDSALKQKCLLTTEL |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the outer limiting membrane, retinal pigment epithelium, outer nuclear layer and outer plexiform layer of the retina (at protein level).
Gene expression databases
Interaction
Subunit
Component of a complex composed of PALS1, CRB1 and EPB41L5 (By similarity).
Within the complex, interacts (via FERM domain) with PALS1 (via HOOK domain) and with CRB1 (via intracellular domain) (By similarity).
Interacts with CRB2 (via intracellular domain) (By similarity).
Interacts with CRB3 (via intracellular domain) (By similarity).
Within the complex, interacts (via FERM domain) with PALS1 (via HOOK domain) and with CRB1 (via intracellular domain) (By similarity).
Interacts with CRB2 (via intracellular domain) (By similarity).
Interacts with CRB3 (via intracellular domain) (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 29-119 | Required for interaction with CRB1 | ||||
Sequence: AATHIPAAGDAKSVITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLR | ||||||
Domain | 43-327 | FERM | ||||
Sequence: ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPTQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRG | ||||||
Region | 356-375 | Disordered | ||||
Sequence: TKTNKARRSTSFERRPSKRY | ||||||
Region | 396-422 | Disordered | ||||
Sequence: NASAQNNDSQQAWGMKSPVPVTSFSSS |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q5FVG2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length731
- Mass (Da)81,718
- Last updated2008-04-29 v2
- ChecksumFB21417F2172D7FD
Q5FVG2-2
- Name2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AQR4 | A0A8I6AQR4_RAT | Epb41l5 | 704 | ||
D3ZK45 | D3ZK45_RAT | Epb41l5 | 504 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_033042 | 384-393 | in isoform 2 | |||
Sequence: GEVWPCSTGS → ASTAKPDDLG | ||||||
Alternative sequence | VSP_033043 | 447-504 | in isoform 2 | |||
Sequence: PLSIDLLNSPDLLETTIGDVTRPSDTSAPFPAPDDVNVATMSHELEELRADCETLKDD → SATSDRCQRGGHQWNPRALPPPQTAYRNYTDFVHEHNVKNAGAHHDAHLAGRAAMTDI | ||||||
Alternative sequence | VSP_033044 | 505-731 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR03085414 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03085531 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03086285 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03086343 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC090012 EMBL· GenBank· DDBJ | AAH90012.1 EMBL· GenBank· DDBJ | mRNA |