Q5FIU7 · Q5FIU7_LACAC

Function

function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site86ATP (UniProtKB | ChEBI)
Binding site126ATP (UniProtKB | ChEBI)
Binding site131-137ATP (UniProtKB | ChEBI)
Binding site164-167ATP (UniProtKB | ChEBI)
Binding site172ATP (UniProtKB | ChEBI)
Binding site249-250ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-(carboxyamino)imidazole ribonucleotide synthase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylaminoimidazole carboxylase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N5-carboxyaminoimidazole ribonucleotide synthase
  • EC number
  • Short names
    N5-CAIR synthase
  • Alternative names
    • 5-(carboxyamino)imidazole ribonucleotide synthetase

Gene names

    • Name
      purK
    • Ordered locus names
      LBA1560

Organism names

Accessions

  • Primary accession
    Q5FIU7

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain90-279ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    359
  • Mass (Da)
    40,218
  • Last updated
    2005-03-01 v1
  • Checksum
    2BD0AF446230E999
MMALSAKYGGMKVITLDPTPNCPCGQVADKQIVAEYSDVKAIEELAKESDVLTYEFENVDLNALKDVADKVKVPQGTNLLYITKHRLREKNFLRSAGCMTAPYLPVKNMADLKAAIKKIGYNCVLKTCEGGYDGHGQEVLKSDADLENNEHIKEILATGDCILEGWVPFKVEASVMVARNAKGEVPVFPVSENYNAEEILHISIVPARVSKKIYDKAQAIARRIAEAIHLRGILGVELFILDNGDIYVNELAPRPHNSGHYSIEACNFDQFDVHDRAICNWPLPKIKLLSKVVMINVLGQHVAGVRKIIPQKSNWHFHDYGKAEVRHNRKMGHVTILTDDIEKTLQEINDTHIWETKVN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000033
EMBL· GenBank· DDBJ
AAV43377.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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