Q5F641 · BIOH_NEIG1

Function

function

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

Pathway

Cofactor biosynthesis; biotin biosynthesis.

Features

Showing features for binding site, active site.

124920406080100120140160180200220240
Type
IDPosition(s)Description
Binding site14substrate
Active site74Nucleophile
Binding site74-75substrate
Binding site136-140substrate
Active site198
Active site226
Binding site226substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpimelyl-[acyl-carrier protein] methyl ester esterase activity
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Pimeloyl-[acyl-carrier protein] methyl ester esterase
  • EC number
  • Alternative names
    • Biotin synthesis protein BioH
    • Carboxylesterase BioH

Gene names

    • Name
      bioH
    • Ordered locus names
      NGO_1725

Organism names

Accessions

  • Primary accession
    Q5F641

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002044821-249Pimeloyl-[acyl-carrier protein] methyl ester esterase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-232AB hydrolase-1

Sequence similarities

Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    249
  • Mass (Da)
    26,793
  • Last updated
    2023-02-22 v2
  • Checksum
    91D9602615EA6436
MPDAAKKVYLIHGWGANRHAFDDLMPRLPATWPVSAVDLPGHGDAPFAQPFDIEAAADGIAAQIDTSADILGWSLGGLVALYLAARHPDKVRSLCLTASFARLTAAEDYPEGLAAPALGKMVGAFRTDYAKHIKQFLQLQLLHTPDAAEIIGRILPDLARCGTPQALQEALDAAERADARHLLDKIDVPVLLVFGGKDAITPLRMGEYLHRHLKGSRLVVMEKAAHAPFLSHAEAFAALCRDFVEGGLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004969
EMBL· GenBank· DDBJ
AAW90346.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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