Q5F5C8 · BICOA_NEIG1

Function

function

Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins.
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.

Catalytic activity

Cofactor

NH4+ (UniProtKB | Rhea| CHEBI:28938 )

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: A monovalent cation. Ammonium or potassium.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site344-351ATP (UniProtKB | ChEBI)
Binding site426substrate
Binding site433-436substrate
Active site435Proton acceptor
Binding site458ATP (UniProtKB | ChEBI)
Binding site508substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionbiotin-[acetyl-CoA-carboxylase] ligase activity
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process
Biological Processprotein modification process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional enzyme BirA/CoaX

Including 2 domains:

  • Recommended name
    Biotin--[acetyl-CoA-carboxylase] synthetase
  • EC number
  • Alternative names
    • Biotin--protein ligase
  • Recommended name
    Type III pantothenate kinase
  • EC number
  • Alternative names
    • PanK-III
    • Pantothenic acid kinase

Gene names

    • Name
      birA/coaX
    • Ordered locus names
      NGO2001

Organism names

Accessions

  • Primary accession
    Q5F5C8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002708821-592Bifunctional enzyme BirA/CoaX

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-329Biotin--protein ligase
Domain83-259BPL/LPL catalytic
Region336-592Type III pantothenate kinase

Sequence similarities

In the N-terminal section; belongs to the biotin--protein ligase family.
In the C-terminal section; belongs to the type III pantothenate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    592
  • Mass (Da)
    64,167
  • Last updated
    2005-03-15 v1
  • Checksum
    1FEA35BF638D2BF6
MTVLKPSHWRVLAELADGLPQHVSQLAREADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRDLGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWAFDRPQYELGSLSPVAALACRRALGCLGLETQIKWPNDLVVGRDKLGGILIETVRAGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAAVLLETLLAELGAVLEQYAEEGFAPFLNEYETANRDHGKAVLLLRDGETVCEGTVKGVDGRGVLHLETAEGEQTVVSGEISLRPDNRSVSVPKRPDSERFLLLEGGNSRLKWAWVENGTFATVGSAPYRDLSPLGAEWAEKADGNVRIVGCAVCGESKKAQVKEQLARKIEWLPSSAQALGIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNRPAGKRYPFPTTTGNAVASGMMDAVCGSIMMMHGRLKEKNGAGKPVDVIITGGGAAKVAEALPPAFLAENTVRVADNLVIHGLLNLIAAEGGESEHA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004969
EMBL· GenBank· DDBJ
AAW90609.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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