Q5F2L2 · FUT10_MOUSE
- ProteinAlpha-(1,3)-fucosyltransferase 10
- GeneFut10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids481 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity).
Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (PubMed:23986452).
Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (PubMed:23986452).
Pathway
Protein modification; protein glycosylation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | nucleoplasm | |
Molecular Function | alpha-(1->3)-fucosyltransferase activity | |
Biological Process | cerebral cortex radially oriented cell migration | |
Biological Process | fucosylation | |
Biological Process | N-glycan fucosylation | |
Biological Process | neuroblast migration | |
Biological Process | neuronal stem cell division | |
Biological Process | neuronal stem cell population maintenance | |
Biological Process | oligosaccharide biosynthetic process | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-(1,3)-fucosyltransferase 10
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ5F2L2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Golgi apparatus membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-8 | Cytoplasmic | ||||
Sequence: MVRFQRRK | ||||||
Transmembrane | 9-31 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: LLASCLCVTATVFLMVTLQVVVE | ||||||
Topological domain | 32-481 | Lumenal | ||||
Sequence: LGKFERKKLKDSNVQDGHRDVEGEPKHLEPFPEKEALALAGRTKVDAGSYPIVLWWSPLTGETGRLGQCGADACFFTINRTFQHHPMTRAFLFYGTDFNIDSLPLPREAHHDWALFHEESPKNNYKLFHKPVITLFNHTATFSRHSHLPLTTQYLEGVDVLKSLRYLVPLQAKNNLRQKLAPLVYVQSDCDPPSDRDSYVRELMAYIEVDSYGECLQNRDLPQQLKNPASMDADAFYRVIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPTIADWLPSNRSAILVSEFSHPRELASFIRRLDYDDGLYETYVEWKLKGKISNQRLLTALNEREWGVQDINQDNYIDSFECMVCRRVWANSRLQEQGLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000299003 | 1-481 | Alpha-(1,3)-fucosyltransferase 10 | |||
Sequence: MVRFQRRKLLASCLCVTATVFLMVTLQVVVELGKFERKKLKDSNVQDGHRDVEGEPKHLEPFPEKEALALAGRTKVDAGSYPIVLWWSPLTGETGRLGQCGADACFFTINRTFQHHPMTRAFLFYGTDFNIDSLPLPREAHHDWALFHEESPKNNYKLFHKPVITLFNHTATFSRHSHLPLTTQYLEGVDVLKSLRYLVPLQAKNNLRQKLAPLVYVQSDCDPPSDRDSYVRELMAYIEVDSYGECLQNRDLPQQLKNPASMDADAFYRVIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPTIADWLPSNRSAILVSEFSHPRELASFIRRLDYDDGLYETYVEWKLKGKISNQRLLTALNEREWGVQDINQDNYIDSFECMVCRRVWANSRLQEQGLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD | ||||||
Glycosylation | 110 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 168 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 318 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 468 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed, with a higher expression in liver and thymus.
Developmental stage
Expressed by Lewis X-positive neural precursor cells in the ventricular and subventricular zones of 15.5 dpc embryonic brain.
Gene expression databases
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q5F2L2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsFut10A
- Length481
- Mass (Da)55,707
- Last updated2005-03-15 v1
- Checksum4CEC3DB4469F754D
Q5F2L2-2
- Name2
- Differences from canonical
- 405-481: GLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD → VSEWKSGGWHGPSLCVVLVFLLWWLPATGLYS
Q5F2L2-3
- Name3
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_027507 | 127-136 | in isoform 3 | |||
Sequence: TDFNIDSLPL → LTTQTMEGRC | ||||||
Alternative sequence | VSP_027508 | 137-481 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 335 | in Ref. 3; AAH22579 | ||||
Sequence: S → N | ||||||
Alternative sequence | VSP_027509 | 405-481 | in isoform 2 | |||
Sequence: GLPPKQWKADVSHLHCPEPALFTFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKD → VSEWKSGGWHGPSLCVVLVFLLWWLPATGLYS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ880009 EMBL· GenBank· DDBJ | CAI53944.1 EMBL· GenBank· DDBJ | mRNA | ||
AK083041 EMBL· GenBank· DDBJ | BAC38741.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147136 EMBL· GenBank· DDBJ | BAE27706.1 EMBL· GenBank· DDBJ | mRNA | ||
AK169153 EMBL· GenBank· DDBJ | BAE40932.1 EMBL· GenBank· DDBJ | mRNA | ||
BC022579 EMBL· GenBank· DDBJ | AAH22579.1 EMBL· GenBank· DDBJ | mRNA | ||
BC030474 EMBL· GenBank· DDBJ | AAH30474.1 EMBL· GenBank· DDBJ | mRNA | ||
BC062113 EMBL· GenBank· DDBJ | AAH62113.1 EMBL· GenBank· DDBJ | mRNA |