Q5F2C5 · Q5F2C5_MOUSE

  • Protein
    Long-chain-fatty-acid--CoA ligase
  • Gene
    Acsl6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

Catalytic activity

  • (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.15 (UniProtKB | ENZYME | Rhea)
  • (E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA
    This reaction proceeds in the forward direction.
  • a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate
    This reaction proceeds in the forward direction.
    EC:6.2.1.3 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Molecular FunctionATP binding
Molecular Functionlong-chain fatty acid-CoA ligase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Long-chain-fatty-acid--CoA ligase
  • EC number
  • Alternative names
    • Acyl-CoA synthetase
    • Long-chain acyl-CoA synthetase

Gene names

    • Name
      Acsl6

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5F2C5

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type III membrane protein
Membrane
; Single-pass type III membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass type III membrane protein

PTM/Processing

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain82-265AMP-dependent synthetase/ligase
Domain274-445AMP-dependent synthetase/ligase

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    622
  • Mass (Da)
    69,570
  • Last updated
    2008-02-05 v1
  • Checksum
    B05D013037406645
MQTQEILRILRLPELSDLGQFFRSLSATTLDGGGARRSVIGGCTQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFVGVFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSISYIINTADICTVIVDKPHKATLLLEHVERKETPGLKLVILMEPFEDALRERGKKCGVDIKSMQAIEDCGRENHHAPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEFAAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTCKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKKGIEGTYQELCMKKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYLVSV

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q91WC3ACSL6_MOUSEAcsl6697
Q5ICG5Q5ICG5_MOUSEAcsl6697
B0QZJ6B0QZJ6_MOUSEAcsl6192
E9Q7Y2E9Q7Y2_MOUSEAcsl6365
Q8R1X1Q8R1X1_MOUSEAcsl6722
Q8C028Q8C028_MOUSEAcsl6359
B1ARG5B1ARG5_MOUSEAcsl6139
F6WYN6F6WYN6_MOUSEAcsl6126
Q8BYJ0Q8BYJ0_MOUSEAcsl6424

Keywords

Genome annotation databases

Similar Proteins

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