Q5E6U6 · Q5E6U6_ALIF1
- ProteinApolipoprotein N-acyltransferase
- Genelnt
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids504 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Catalytic activity
- N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] + a glycerophospholipid = N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] + a 2-acyl-sn-glycero-3-phospholipid + H+
Pathway
Protein modification; lipoprotein biosynthesis (N-acyl transfer).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | N-acyltransferase activity | |
Biological Process | lipoprotein biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameApolipoprotein N-acyltransferase
- EC number
- Short namesALP N-acyltransferase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Aliivibrio
Accessions
- Primary accessionQ5E6U6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 28-46 | Helical | ||||
Sequence: YSLWAFAFIAPLILLLLMH | ||||||
Transmembrane | 53-72 | Helical | ||||
Sequence: ATWLGFVWGLGYFGAGVSWV | ||||||
Transmembrane | 84-109 | Helical | ||||
Sequence: VAASLFLMIGLISYLSLYPMLFAFLL | ||||||
Transmembrane | 121-147 | Helical | ||||
Sequence: YLLAAPALWIITDWLRGWVFTGFPWLW | ||||||
Transmembrane | 159-182 | Helical | ||||
Sequence: AWGPILGVEGITVMILLSVGTMAY | ||||||
Transmembrane | 189-208 | Helical | ||||
Sequence: WGLLLIPAVIFATSFAIKPF | ||||||
Transmembrane | 479-497 | Helical | ||||
Sequence: YWGSIPLYLLVGLFLLVAW |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 224-470 | CN hydrolase | ||||
Sequence: IQGNVNQAIKWLPSERWPTIMKYMDLTRKNWDADVIVWPEAAIPALEIEIPSFLRNLDSAATMNNSTVITGIVGQSPTGNFYNNIISLGVNGTNGYDYGQQPRYSKHHLLPFGEFVPFENLLRPIAPIFNLPMSSFSRGDYIQPNMEASGSHLAPALCYEIVYGEQVRENITSQTDYILTLSNDAWFGTSIGPLQHMEMAQMRALEIGKPVIRSTNNGVTAITDHKGQITKQIPQFTTAVLRGEVIP |
Sequence similarities
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length504
- Mass (Da)56,378
- Last updated2005-03-15 v1
- Checksum6A5A60CD30E245E7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000020 EMBL· GenBank· DDBJ | AAW85250.1 EMBL· GenBank· DDBJ | Genomic DNA |