Q5E256 · Q5E256_ALIF1
- ProteinPhosphoribosylamine--glycine ligase
- GenepurD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids430 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H+ + N1-(5-phospho-beta-D-ribosyl)glycinamide + phosphate
Cofactor
Protein has several cofactor binding sites:
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylamine-glycine ligase activity | |
Biological Process | 'de novo' IMP biosynthetic process | |
Biological Process | purine nucleobase biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosylamine--glycine ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Aliivibrio
Accessions
- Primary accessionQ5E256
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 109-316 | ATP-grasp | ||||
Sequence: KDFLARHDIPTGSYANFTEIEPALAYVREQGAPIVVKADGLAAGKGVIVAMTLEEAEDAIKDMLAGNAFGEAGSRVVIEEFLEGEEASFIVMVDGASVLPMATSQDHKRVGDKDTGPNTGGMGAYSPAPVVTPEIHNRILEEVIYPTVRGMDAEGAPYTGFLYAGLMIDTEGTPKVIEYNCRFGDPETQPIMMRMESDLVELCLMAID | ||||||
Region | 212-235 | Disordered | ||||
Sequence: SQDHKRVGDKDTGPNTGGMGAYSP |
Sequence similarities
Belongs to the GARS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length430
- Mass (Da)45,730
- Last updated2005-03-15 v1
- Checksum1AE178734F1D0D67
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000020 EMBL· GenBank· DDBJ | AAW86890.1 EMBL· GenBank· DDBJ | Genomic DNA |