Q5DU00 · DCDC2_MOUSE

  • Protein
    Doublecortin domain-containing protein 2
  • Gene
    Dcdc2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity).
May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
Involved in the control of ciliogenesis and ciliary length (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxoneme
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentkinocilium
Cellular Componentsynapse
Biological Processcilium assembly
Biological Processdendrite morphogenesis
Biological Processintracellular signal transduction
Biological Processneuron migration
Biological Processneuronal action potential
Biological Processregulation of cilium assembly
Biological Processregulation of Wnt signaling pathway
Biological Processsensory perception of sound
Biological Processsynaptic transmission, glutamatergic
Biological Processvisual learning

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Doublecortin domain-containing protein 2

Gene names

    • Name
      Dcdc2
    • Synonyms
      Dcdc2a, Kiaa1154

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q5DU00
  • Secondary accessions
    • Q5SZU0
    • Q80Y99

Proteomes

Organism-specific databases

Subcellular Location

Note: Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.

Keywords

Phenotypes & Variants

Disruption phenotype

Animals develop periportal hepatic fibrosis with biliary duct proliferation at age 11 months.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000798051-475Doublecortin domain-containing protein 2
Modified residue270Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in hair cells of the inner ear.

Gene expression databases

Interaction

Subunit

Interacts with DVL1, DVL2 and DVL3.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain17-100Doublecortin 1
Domain139-221Doublecortin 2
Region234-475Disordered
Compositional bias251-272Polar residues
Compositional bias273-292Basic and acidic residues
Compositional bias312-361Basic and acidic residues
Compositional bias378-409Basic and acidic residues
Compositional bias422-438Basic and acidic residues
Compositional bias453-475Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q5DU00-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    475
  • Mass (Da)
    51,953
  • Last updated
    2005-07-19 v2
  • Checksum
    B4195FC005B62F4A
MNGPSSRSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKKLNYLDIGEIKKRPMEAVNTEVKPVIHSRINVSARFRKSLHEPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKRLPYSELLFDKSAMRRPYGQKASSLPPMVGSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKEDFSAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKSSPSRVNGGTDEENGEELDQVAEELQPTEDEKGKAEGDNSGQDEAGLDAQRPPRPEVTVTSPQENEENEANKASSAVA

Q5DU00-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 308-368: EGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKEDFSAM → WLIKVERDTCLRPQLDGNRNRVTALPPYPWSIHTRHMWDAPGEDRWKKVTNKAQPTYGHSM
    • 369-475: Missing

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
R4GML1R4GML1_MOUSEDcdc2a475

Sequence caution

The sequence BAD90429.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias251-272Polar residues
Compositional bias273-292Basic and acidic residues
Alternative sequenceVSP_014672308-368in isoform 2
Compositional bias312-361Basic and acidic residues
Alternative sequenceVSP_014673369-475in isoform 2
Compositional bias378-409Basic and acidic residues
Sequence conflict398in Ref. 2; CAI24561
Compositional bias422-438Basic and acidic residues
Sequence conflict424in Ref. 2; CAI24561
Compositional bias453-475Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK220370
EMBL· GenBank· DDBJ
BAD90429.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL589735
EMBL· GenBank· DDBJ
CAI24561.1
EMBL· GenBank· DDBJ
Genomic DNA
BC045136
EMBL· GenBank· DDBJ
AAH45136.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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