Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q5D184 · Q5D184_APIME

Function

Features

Showing features for binding site, active site.

1996100200300400500600700800900
Type
IDPosition(s)Description
Binding site639-647ATP (UniProtKB | ChEBI)
Binding site667ATP (UniProtKB | ChEBI)
Active site760Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functiontransmembrane-ephrin receptor activity
Biological Processaxon guidance
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      EphR
    • Synonyms
      Eph

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis

Accessions

  • Primary accession
    Q5D184
  • Secondary accessions
    • A0A8B6WZ05

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane533-556Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_503554403719-996receptor protein-tyrosine kinase
Disulfide bond62↔178
Disulfide bond97↔107

Keywords

Family & Domains

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    996
  • Mass (Da)
    109,976
  • Last updated
    2005-03-29 v1
  • MD5 Checksum
    4D3B83EAE6A050D463471B34FB16132B
MFPVRSIFFLSLVSVVLLDTTQEEKLEWTKYPFGAEANTPGWVEESFTNFDKGINWRSYVVCDVAYNNVNNWLWTPFIERGPANRMYIEIKFTTRDCSLFPGNALSCKETFSLLYYEFDVATKEPPPWETDSYKLIGRIAAGEGRFNTNTEVVINTEVKSIPVTKKGVYFAFRDQGACISILAIKVYYISCPEISVNFAHFPATPTGREVALIEQTIGTCVANAVVIEQPTFLCKGDGKWYLPSGGCHCKPGYQADVEKQECTECPIGKFKHEAGSHSCEACPAHSKSSDYGFTECRCDPGYFRAEKDPKKMPCTQPPSAPQNLTVNFVDQSTVFLSWNAPHMLGGRTDTTYRVVCDACSMGVKYIPNTEVFNDTKITITGLNAVTTYRFQVFAENGVSALAGKSEYVDITVTTDASVPSLVSNVRITSVKSSELSISWDAPITEIGGDSDLVERYEVRCYPRYDDATNATVIQTSELSATFKGLKPSTDYAIQVRAKTTRGWGEYTPVVYKKTPHAMGLDYVGEDDNMQVRIIAGAIVAVVVLLVIIIIMTVLILRRASDECNKKQPSDCDTLEYRNGEVTTPLFTPAVGVAAASAGGAGGGGARSYVDPHTYEDPNQAVREFAREIDAGYITIEAIIGGGEFGDVCRGKLKLPPDGRTEIDVAIKTLKPGSADKARNDFLTEASIMGQFEHPNVIFLQGVVTKSNPVMIITEFMENGSLDTFLRANDGKFQVLQLVGMLRGIASGMQYLAEMNYVHRDLAARNVLVNAALVCKIADFGLSREIESATEGAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSMGIVCWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAIYQLMLDCWQKERTHRPTFANLTQTLDKLIRSPDTLRKIAQNRGTNPLAPDAVDLTQLTSVSEWLASIKMSRYAESFERSGVTTLEAAARVTVQELTALGVTLVGHQKKIMNSVTALRAQMSATSQGFLV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7M7GY04A0A7M7GY04_APIMEEphR1050

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help