Q5CYC1 · Q5CYC1_CRYPI
- ProteinDNA replication licensing factor MCM5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids791 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | MCM complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA replication origin binding | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity | |
Biological Process | DNA duplex unwinding | |
Biological Process | DNA replication initiation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication licensing factor MCM5
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium
Accessions
- Primary accessionQ5CYC1
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 387-593 | MCM | ||||
Sequence: IHELIVNSIAPAIYGNETIKQAIACLLFSGSSKCLPDGNRIRGDLNVLLLGDPSTAKSQLLKFVEQVAPICIYTSGKGSSAAGLTAAIVKDHANGVYALEGGAMVLADGGVVCIDEFDKMRDDDRVAIHEAMEQQTISIAKAGITTILKARCSILAAANPTFGSYDDSKDLTQQHDFESTILSRFDLIFLLKDEKNVERDKLIASHI |
Sequence similarities
Belongs to the MCM family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length791
- Mass (Da)88,302
- Last updated2005-04-12 v1
- Checksum7E8692F4A70E89F3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAEE01000001 EMBL· GenBank· DDBJ | EAK90304.1 EMBL· GenBank· DDBJ | Genomic DNA |