Q5CYC1 · Q5CYC1_CRYPI

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular ComponentMCM complex
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA replication origin binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Biological ProcessDNA duplex unwinding
Biological ProcessDNA replication initiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM5
  • EC number

Gene names

    • ORF names
      cgd7_2920

Organism names

  • Taxonomic identifier
  • Strain
    • Iowa II
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium

Accessions

  • Primary accession
    Q5CYC1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the MCM2-7 complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain387-593MCM

Sequence similarities

Belongs to the MCM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    791
  • Mass (Da)
    88,302
  • Last updated
    2005-04-12 v1
  • Checksum
    7E8692F4A70E89F3
MQNSIGTIYYSHPTRDLEKGDWNNDTVNSSVGLLSLEECRSKFSNFIKNFNQGGEYIYREMLINNISIGEYTLRLELHHLSIDEVSCSEMGENTENASYDGNLIDGQENDSDNFVNGVRTSNELCCLIQCFKNAPLKYIPICEGVLKEVYLELVGKHKKEISEEEINEIVPDIQLQIVSNQEPTLIRDLRSNVMEKLVTVPGIVIQSSKPQKKASKLKILCRQCKGTRNINIPIWRQGTMLPRVCNTTPIGDAPKCPLDPYFTLCDESEYIDIQSMKFQELPEHVPTGDIPRNISLHMTRGLIDKVIPGNRLYVVGVLSSTDKESSKAHSSSRNGSLRTSYLYVIGVMNYGSSWSNKNTNTLIKNSSISNQYNEIEEFRRISSLPNIHELIVNSIAPAIYGNETIKQAIACLLFSGSSKCLPDGNRIRGDLNVLLLGDPSTAKSQLLKFVEQVAPICIYTSGKGSSAAGLTAAIVKDHANGVYALEGGAMVLADGGVVCIDEFDKMRDDDRVAIHEAMEQQTISIAKAGITTILKARCSILAAANPTFGSYDDSKDLTQQHDFESTILSRFDLIFLLKDEKNVERDKLIASHIVELHSGIKGKINGDCSESTNSLQFEQLQKYINYCREFIHPRLSLDAAAILENFYVKIREDNREDTNKASKDRIPITVRQLEAITRIAESFAKMEMQNIASEKHVEMAIKLFKNATIEAIKSNILLLDNLSPAEQSAIIDAEVAIKNRIPIKARAGKATIVKDLALIGYDPYYLTKAMKILIQKGDLIERSDFSIFRVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAEE01000001
EMBL· GenBank· DDBJ
EAK90304.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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