Q5CQG8 · Q5CQG8_CRYPI

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      cgd4_780

Organism names

  • Taxonomic identifier
  • Strain
    • Iowa II
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium

Accessions

  • Primary accession
    Q5CQG8

Proteomes

Organism-specific databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain, coiled coil.

TypeIDPosition(s)Description
Compositional bias295-337Polar residues
Region295-399Disordered
Compositional bias338-362Acidic residues
Compositional bias379-399Polar residues
Domain580-695Toprim
Region1023-1045Disordered
Coiled coil1370-1420
Region1440-1797Disordered
Compositional bias1486-1509Acidic residues
Compositional bias1565-1587Polar residues
Compositional bias1621-1704Polar residues
Compositional bias1705-1722Basic and acidic residues
Compositional bias1723-1738Polar residues
Compositional bias1739-1753Basic and acidic residues
Compositional bias1754-1777Acidic residues

Sequence similarities

Belongs to the type II topoisomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,797
  • Mass (Da)
    204,211
  • Last updated
    2005-04-12 v1
  • Checksum
    E7A7D707E5968DC0
MILEENQLENNELISNSKITSKPKMVNKSKKTVEERYQKKTQIEHILLRPDTYIGSTEFHEQALWVWDDSNMKMVYKTINYVPGLYKIFDEILVNAADVKAREISTKNNHIFEKCTCIKVEINREKKEITVFNDGEGIPIEIHREHQVYVPELIFGHLLTSDNYDDNEDRVTGGRNGFGAKLTNIFSKEFKVECGDNNTGRIFKMTWYDNMSKKSEENIKENYSGKSYVKITFKPDLSRFGNMKDFDDDIISLLNKRVYDISGTSGVKVYLNGSLIPIKDFKSYTLLYLKSRMNNTNNIENNNNNNNNNEKKTSTTRTLRNTNKKNMSKNNSYDDEFENYNVENEDEYDNNFEEDIMEDDEWDDEPKSSKKKNSNSNSKKKKLGQNGNGSSSSLILSGGGGSDTNSPLIIYESVPKWEIVISESDGGQFQHVSFVNSICTIKGGTHISYVLDPLINAILKKVQTKNKGGMDVKSNHVKNHIWIFIKCLIVNPSFDSQTKETLTTKVSKFGSVCTLSEKTINSVVKSSIVENVLMWAQLKQSMELKKKMKSNQKNTVTSRLLGIPKLEDANEAGGPHSKKCTLILTEGDSAKTSCLAGLSIVGRDYFGVFPLRGKLLNVREASFKQQIGNVEIQNILKILGLGIGQKYDNGPVNLRYGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLIHFRGFLKQFVTPIVKAKKGSNEISFFTLYEYEQWRKNNSSNLNGWRFKYYKGLGTSTDLEFKEYFTKIENHSIEFDWMDDQDDEAIDMAFSKKRTEDRKNWIESYKEGTYVDYSINNQCRNLRYFDFIHKELVLFSRYDTTRSIPNLLDGLKPGQRKVLFATFKKKLNNELKVAQLAGYVAEHSAYHHGESSLQSTIVNMAQNFVGSNNLNLLEPCGQFGSRKEGGKDASAARYIFTKLSKWTRYIFPEADDPLLTYLYDDGQQIEPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLKGEMMVPMTPWYKSFKGKIFPIKQKSKKNSASNGGGNNNRKKTAINSFNNGSNSSILIGSQVDAEDDDLQQIQRTNNMGNGIIEETLELGANYETFGNWYKKNEETLVITELPVRRWTQDYKEWLESTLLPAPNADNDNIENSWIIDYRDNSSHESVHITVRMRPEKLQQAEMEGIEKIFRLKSTLSTSNMTLFDHNSRIVRYETELDILKEFIPIRLEMYEKRKNYLLSKLNYEKCLLEQKILFLKLVIQGVIGLSNKSKETLVSDLKKNNIKSIKQVQELTQWVGVGGSNLAQNSISGSGIGGNPSFVDSGDNSMDYINFEMNSFDYLESSQQDGILESTSYSRETNKGNELKLFDYLLSMPLWSLTKEKMELLEADLIKKTEEYEKLLKTSIEEIWNTELDELLKVIEEEETQDELIEAEHNSLIQKRRLSVDWNDSKKKKTGASRKRKNETTKKQESLKVKNPQKSNLKKTSAKPTKKSRIDDSDEEDDYIDGDNYSDEDDYYDDIGDDFYGSDNSNDSNDRIILNNEESENEEFDNLTSDLDDISDDGGVGNKGKRTQKTLANKSKTDNQGKTKLNNLKKAKNTSSVKSSSKDKKQGLLKVPKSTGGNSFGGIGGGVAGTGISNTNSSSTSNNTSTKKENIESSSSKPLESVSXLQRLQQRTNLVNSLNQSLNSLSSNLTKVASTTSSSSSGGVPATKQTKITDLFKSKDSEDIESRTAKSGSQKKQNSQNSENEIISRPKRGKRKTIIESEEEEEDGEEEEEEDDDDEIEDQESVSNISSDSLKESDFSEYSDF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias295-337Polar residues
Compositional bias338-362Acidic residues
Compositional bias379-399Polar residues
Compositional bias1486-1509Acidic residues
Compositional bias1565-1587Polar residues
Compositional bias1621-1704Polar residues
Compositional bias1705-1722Basic and acidic residues
Compositional bias1723-1738Polar residues
Compositional bias1739-1753Basic and acidic residues
Compositional bias1754-1777Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAEE01000009
EMBL· GenBank· DDBJ
EAK87659.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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