Q5CQG8 · Q5CQG8_CRYPI
- ProteinDNA topoisomerase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1797 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium
Accessions
- Primary accessionQ5CQG8
Proteomes
Organism-specific databases
Interaction
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 295-337 | Polar residues | ||||
Sequence: NTNNIENNNNNNNNNEKKTSTTRTLRNTNKKNMSKNNSYDDEF | ||||||
Region | 295-399 | Disordered | ||||
Sequence: NTNNIENNNNNNNNNEKKTSTTRTLRNTNKKNMSKNNSYDDEFENYNVENEDEYDNNFEEDIMEDDEWDDEPKSSKKKNSNSNSKKKKLGQNGNGSSSSLILSGG | ||||||
Compositional bias | 338-362 | Acidic residues | ||||
Sequence: ENYNVENEDEYDNNFEEDIMEDDEW | ||||||
Compositional bias | 379-399 | Polar residues | ||||
Sequence: KKKKLGQNGNGSSSSLILSGG | ||||||
Domain | 580-695 | Toprim | ||||
Sequence: CTLILTEGDSAKTSCLAGLSIVGRDYFGVFPLRGKLLNVREASFKQQIGNVEIQNILKILGLGIGQKYDNGPVNLRYGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLIHFRGFLK | ||||||
Region | 1023-1045 | Disordered | ||||
Sequence: SKKNSASNGGGNNNRKKTAINSF | ||||||
Coiled coil | 1370-1420 | |||||
Sequence: MELLEADLIKKTEEYEKLLKTSIEEIWNTELDELLKVIEEEETQDELIEAE | ||||||
Region | 1440-1797 | Disordered | ||||
Sequence: KKTGASRKRKNETTKKQESLKVKNPQKSNLKKTSAKPTKKSRIDDSDEEDDYIDGDNYSDEDDYYDDIGDDFYGSDNSNDSNDRIILNNEESENEEFDNLTSDLDDISDDGGVGNKGKRTQKTLANKSKTDNQGKTKLNNLKKAKNTSSVKSSSKDKKQGLLKVPKSTGGNSFGGIGGGVAGTGISNTNSSSTSNNTSTKKENIESSSSKPLESVSXLQRLQQRTNLVNSLNQSLNSLSSNLTKVASTTSSSSSGGVPATKQTKITDLFKSKDSEDIESRTAKSGSQKKQNSQNSENEIISRPKRGKRKTIIESEEEEEDGEEEEEEDDDDEIEDQESVSNISSDSLKESDFSEYSDF | ||||||
Compositional bias | 1486-1509 | Acidic residues | ||||
Sequence: DEEDDYIDGDNYSDEDDYYDDIGD | ||||||
Compositional bias | 1565-1587 | Polar residues | ||||
Sequence: NKSKTDNQGKTKLNNLKKAKNTS | ||||||
Compositional bias | 1621-1704 | Polar residues | ||||
Sequence: GTGISNTNSSSTSNNTSTKKENIESSSSKPLESVSXLQRLQQRTNLVNSLNQSLNSLSSNLTKVASTTSSSSSGGVPATKQTKI | ||||||
Compositional bias | 1705-1722 | Basic and acidic residues | ||||
Sequence: TDLFKSKDSEDIESRTAK | ||||||
Compositional bias | 1723-1738 | Polar residues | ||||
Sequence: SGSQKKQNSQNSENEI | ||||||
Compositional bias | 1739-1753 | Basic and acidic residues | ||||
Sequence: ISRPKRGKRKTIIES | ||||||
Compositional bias | 1754-1777 | Acidic residues | ||||
Sequence: EEEEEDGEEEEEEDDDDEIEDQES |
Sequence similarities
Belongs to the type II topoisomerase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,797
- Mass (Da)204,211
- Last updated2005-04-12 v1
- ChecksumE7A7D707E5968DC0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 295-337 | Polar residues | ||||
Sequence: NTNNIENNNNNNNNNEKKTSTTRTLRNTNKKNMSKNNSYDDEF | ||||||
Compositional bias | 338-362 | Acidic residues | ||||
Sequence: ENYNVENEDEYDNNFEEDIMEDDEW | ||||||
Compositional bias | 379-399 | Polar residues | ||||
Sequence: KKKKLGQNGNGSSSSLILSGG | ||||||
Compositional bias | 1486-1509 | Acidic residues | ||||
Sequence: DEEDDYIDGDNYSDEDDYYDDIGD | ||||||
Compositional bias | 1565-1587 | Polar residues | ||||
Sequence: NKSKTDNQGKTKLNNLKKAKNTS | ||||||
Compositional bias | 1621-1704 | Polar residues | ||||
Sequence: GTGISNTNSSSTSNNTSTKKENIESSSSKPLESVSXLQRLQQRTNLVNSLNQSLNSLSSNLTKVASTTSSSSSGGVPATKQTKI | ||||||
Compositional bias | 1705-1722 | Basic and acidic residues | ||||
Sequence: TDLFKSKDSEDIESRTAK | ||||||
Compositional bias | 1723-1738 | Polar residues | ||||
Sequence: SGSQKKQNSQNSENEI | ||||||
Compositional bias | 1739-1753 | Basic and acidic residues | ||||
Sequence: ISRPKRGKRKTIIES | ||||||
Compositional bias | 1754-1777 | Acidic residues | ||||
Sequence: EEEEEDGEEEEEEDDDDEIEDQES |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAEE01000009 EMBL· GenBank· DDBJ | EAK87659.1 EMBL· GenBank· DDBJ | Genomic DNA |