Q5BJ41 · CNOT6_XENLA
- ProteinCCR4-NOT transcription complex subunit 6
- Genecnot6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids552 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Poly(A) nuclease involved in mRNA decay. Has 3'-5' RNase activity (PubMed:20634287).
The CCR4-NOT complex functions as a general transcription regulation complex (By similarity).
Enhances ligand-dependent transcriptional activity of nuclear hormone receptors (By similarity).
The CCR4-NOT complex functions as a general transcription regulation complex (By similarity).
Enhances ligand-dependent transcriptional activity of nuclear hormone receptors (By similarity).
Catalytic activity
Cofactor
Note: Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 235 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 235 | substrate | ||||
Sequence: E | ||||||
Binding site | 271 | substrate | ||||
Sequence: E | ||||||
Binding site | 356 | substrate | ||||
Sequence: H | ||||||
Binding site | 361 | substrate | ||||
Sequence: P | ||||||
Active site | 407 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 407 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 409 | substrate | ||||
Sequence: N | ||||||
Binding site | 476 | substrate | ||||
Sequence: N | ||||||
Binding site | 481 | substrate | ||||
Sequence: F |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | CCR4-NOT complex | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | nuclear receptor coactivator activity | |
Molecular Function | poly(A)-specific ribonuclease activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA exonuclease activity | |
Biological Process | miRNA-mediated gene silencing by mRNA destabilization | |
Biological Process | nuclear-transcribed mRNA catabolic process, no-go decay | |
Biological Process | nuclear-transcribed mRNA poly(A) tail shortening | |
Biological Process | regulation of translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCCR4-NOT transcription complex subunit 6
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ5BJ41
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000218576 | 1-552 | CCR4-NOT transcription complex subunit 6 | |||
Sequence: MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSSSLWSLTHLTALHLSDNSLSCIPSDIAKLHNLVYLDLSHNQIQSLPAELGNMVSLRELHLNYNQLRVLPFELGKLFQLQTLSLKGNPLTQDILNLCLEPDGTRRLLNYLLDNLSVSTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIISLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCNGKNGMTNGRITHGFKLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR |
Interaction
Subunit
Subunit of the CCR4-NOT core complex.
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 52-73 | LRR 1 | ||||
Sequence: HLTALHLSDNSLSCIPSDIAKL | ||||||
Repeat | 75-96 | LRR 2 | ||||
Sequence: NLVYLDLSHNQIQSLPAELGNM | ||||||
Repeat | 98-120 | LRR 3 | ||||
Sequence: SLRELHLNYNQLRVLPFELGKLF | ||||||
Repeat | 121-143 | LRR 4 | ||||
Sequence: QLQTLSLKGNPLTQDILNLCLEP | ||||||
Region | 153-552 | Nuclease domain | ||||
Sequence: LLDNLSVSTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIISLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCNGKNGMTNGRITHGFKLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR |
Sequence similarities
Belongs to the CCR4/nocturin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length552
- Mass (Da)62,776
- Last updated2005-04-12 v1
- Checksum5DC598040C453EFD
Keywords
- Technical term