Q5BGB9 · SAR1_EMENI

Function

function

Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the Sec13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to sar1-GDP triggers coat release and recycles COPII subunits (By similarity).

Catalytic activity

Features

Showing features for binding site.

118920406080100120140160180
TypeIDPosition(s)Description
Binding site27-34GTP (UniProtKB | ChEBI)
Binding site70-73GTP (UniProtKB | ChEBI)
Binding site129-132GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentCOPII vesicle coat
Cellular Componentendoplasmic reticulum exit site
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentmitochondria-associated endoplasmic reticulum membrane contact site
Cellular Componentmitochondrion
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processendoplasmic reticulum membrane organization
Biological Processendoplasmic reticulum to Golgi vesicle-mediated transport
Biological Processintracellular protein transport
Biological Processmembrane organization
Biological Processmitochondrial fission
Biological Processmitochondrial membrane organization
Biological Processnuclear envelope organization
Biological Processpositive regulation of ER to Golgi vesicle-mediated transport
Biological Processpositive regulation of protein exit from endoplasmic reticulum
Biological Processregulation of COPII vesicle coating
Biological Processvesicle organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      sar1
    • ORF names
      AN0411

Organism names

Accessions

  • Primary accession
    Q5BGB9
  • Secondary accessions
    • C8VTH5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002955151-189Small COPII coat GTPase sar1

Interaction

Subunit

COPII is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex and sar1.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the small GTPase superfamily. SAR1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    21,433
  • Last updated
    2005-04-26 v1
  • Checksum
    372CE4A2B97A3325
MWIINWFYDILASLGLLNKHAKLLFLGLDNAGKTTLLHMLKNDRVAILSPTAHPTSEELVIGNNRFTTFDLGGHQQARRLWKDYFPEVSGIVFLVDAKDHERFPESKAELDALLAMEELSKVPFLVLGNKIDHPDAVSEDELRHQLGLYQTTGKGKVPLEGIRPIEVFMCSVVMRQGYGEGIRWLSQYV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000007
EMBL· GenBank· DDBJ
EAA66510.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001308
EMBL· GenBank· DDBJ
CBF89540.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp