Q5BE65 · KDSR_EMENI

Function

function

Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.

Catalytic activity

Pathway

Lipid metabolism; sphingolipid metabolism.

Features

Showing features for binding site, active site.

136950100150200250300350
Type
IDPosition(s)Description
Binding site52NADP+ (UniProtKB | ChEBI)
Binding site55NADPH (UniProtKB | ChEBI)
Binding site57NADPH (UniProtKB | ChEBI)
Binding site59NADPH (UniProtKB | ChEBI)
Binding site80NADPH (UniProtKB | ChEBI)
Binding site84NADPH (UniProtKB | ChEBI)
Binding site110NADP+ (UniProtKB | ChEBI)
Binding site110NADPH (UniProtKB | ChEBI)
Binding site111NADPH (UniProtKB | ChEBI)
Active site213Proton acceptor
Binding site213NADP+ (UniProtKB | ChEBI)
Active site217Lowers pKa of active site Tyr
Binding site217NADP+ (UniProtKB | ChEBI)
Binding site261NADP+ (UniProtKB | ChEBI)
Binding site263NADP+ (UniProtKB | ChEBI)
Binding site272NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function3-dehydrosphinganine reductase activity
Molecular FunctionNADPH binding
Biological Process3-keto-sphinganine metabolic process
Biological Processsphingolipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-ketodihydrosphingosine reductase tsc10
  • EC number
  • Alternative names
    • 3-dehydrosphinganine reductase
    • KDS reductase

Gene names

    • Name
      tsc10
    • ORF names
      AN1165

Organism names

Accessions

  • Primary accession
    Q5BE65
  • Secondary accessions
    • C8VT29

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane195-215Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000547961-3693-ketodihydrosphingosine reductase tsc10

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif55-59GXSXG

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    40,461
  • Last updated
    2011-11-16 v2
  • MD5 Checksum
    6123B4CCD34B47BCAC08097D00F6301A
MHPSLPSIIYDASPTALGISAVFGALFFYTLVKMFGFLARENQFVVEGRTVVITGGSEGMGKAVACQLAQKGANIVIVARTLQKLEEAIEAIKGSAANVNKQRFHYISADLTKPEECERIMTEVTEWNDGMPPDIVWCCAGYCTPGYFVETSVQTLKDQMDTVYWTAANTAHAILRKWLVPINPSHQRPLPRRHLIFTCSTLAFVPIAGYAPYSPAKAAMRALSDTLCQEIEVYNGSRASKERARATPADVKIHTVFPMGILSPGFDNEQQIKPALTKQLESADKPQTPKEVARIAIEAIERGEYLITTMFVGDVMKGAALGPSPRNSWFRDTCTGWLSNLLFLGVVPDLRKQAFNWGAKNGVPTSPSA

Sequence caution

The sequence EAA66283.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000016
EMBL· GenBank· DDBJ
EAA66283.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001308
EMBL· GenBank· DDBJ
CBF88015.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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