Q5BD77 · HOGA1_EMENI
- ProteinProbable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids309 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the final step in the metabolic pathway of hydroxyproline (By similarity).
Involved in osmoadaptation
Involved in osmoadaptation
Catalytic activity
- (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Activity regulation
Inhibited by divalent cations.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 49-50 | substrate | |||
Site | 144 | Involved in proton transfer during cleavage | |||
Active site | 173 | Schiff-base intermediate with substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | (4S)-4-hydroxy-2-oxoglutarate aldolase activity | |
Molecular Function | (R,S)-4-hydroxy-2-oxoglutarate aldolase activity | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionQ5BD77
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000348285 | 1-309 | Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial | ||
Expression
Induction
Down-regulated when grown with elevated levels of potassium chloride.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)32,314
- Last updated2005-04-26 v1
- Checksum42D3E59113B43F66
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACD01000023 EMBL· GenBank· DDBJ | EAA63816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001307 EMBL· GenBank· DDBJ | CBF84998.1 EMBL· GenBank· DDBJ | Genomic DNA |