Q5B8K4 · SEC11_EMENI

Function

function

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).

Catalytic activity

  • Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
    EC:3.4.21.89 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

119220406080100120140160180
TypeIDPosition(s)Description
Active site53Charge relay system
Active site92Charge relay system
Active site134Charge relay system

GO annotations

AspectTerm
Cellular Componentsignal peptidase complex
Molecular Functionpeptidase activity
Molecular Functionserine-type endopeptidase activity
Biological Processprotein targeting to ER
Biological Processsignal peptide processing

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal peptidase complex catalytic subunit sec11
  • EC number
  • Alternative names
    • Signal peptidase I

Gene names

    • Name
      sec11
    • ORF names
      AN3126

Organism names

Accessions

  • Primary accession
    Q5B8K4
  • Secondary accessions
    • C8VIJ4

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-18Cytoplasmic
Transmembrane19-39Helical; Signal-anchor for type II membrane protein
Topological domain40-192Lumenal

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004123291-192Signal peptidase complex catalytic subunit sec11

Interaction

Subunit

Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity).
The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
SPC associates with the translocon complex (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region178-189C-terminal short (CTS) helix

Domain

The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.

Sequence similarities

Belongs to the peptidase S26B family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,363
  • Last updated
    2011-09-21 v2
  • Checksum
    2865DE2529E23F8C
MLSFLSSNLSNTRQSIAQVLNFALVLSTAFMLWKGLSVVTASSSPIVVVLSGSMEPAFQRGDLLFLWNRSPRAEVGEIVVYNVKGKDIPIVHRVVRTFPEVEGKKEKTVKEVTVSTPTPPNMLLTKGDNNLADDTELYARGQEFLHRKEDIVGSVRGYMPMVGYVTIMLSEHPWLKSVLLGIMGLMVILQRE

Sequence caution

The sequence EAA63697.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000051
EMBL· GenBank· DDBJ
EAA63697.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001306
EMBL· GenBank· DDBJ
CBF83359.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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