Q5B3B1 · NDC80_EMENI

Function

function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, centromeric region
Cellular ComponentNdc80 complex
Cellular Componentnucleus
Molecular Functionmicrotubule binding
Biological Processattachment of mitotic spindle microtubules to kinetochore
Biological Processcell division
Biological Processmitotic sister chromatid biorientation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Probable kinetochore protein ndc80

Gene names

    • Name
      ndc80
    • ORF names
      AN4969

Organism names

Accessions

  • Primary accession
    Q5B3B1
  • Secondary accessions
    • C8V902

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002466381-738Probable kinetochore protein ndc80

Interaction

Subunit

Component of the NDC80 complex, which consists of ndc80, nuf2, spc24 and spc25.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, coiled coil.

Type
IDPosition(s)Description
Compositional bias20-144Polar residues
Region20-151Disordered
Coiled coil329-492
Coiled coil582-689

Sequence similarities

Belongs to the NDC80/HEC1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    738
  • Mass (Da)
    84,067
  • Last updated
    2005-04-26 v1
  • Checksum
    B13599A85E883DA0
MSQDTGLFSIKRPRETLGSVQNFSSLPQPSSALKRTSSIGYQNPPFTSQHTRSMSLLNSVGRPQQPNFQRSSSGGFGADPGLSSVRRSVSSNVFHGTSAGRPSFAPGSMSSNPASQSLQRRSSVFSRPSTGGAMGHQSFFTQVPSAAGVPRDPRPLRDRSFQARIAQELLEYLTHNNFELEMKHSLGQNTLRSPTQKDFNYIFQWLYHRIDPGYRFQKAMDAEVPPILKQLRYPYEKGITKSQIAAVGGQNWPTFLGMLHWLMELAQMMDRFAMGEYDEACAEMGVDVSGDRIIFRFLTGAYHDWLQGGEEEDDDAAAQRLIPHIELMAQEFEKGNEKYVQEMQVLDAENRALRDQIEELEKNAPDMAKLDKQFRILEDDKRKFEDYIQNVQGKIEKYESRIAFLEDEIRKTESELQAAEEERAGLQASVDQQGLTIQDIDRMNTERDRLQRSLDDAVSRLEETHARVMAKESEASAKLEDLEELVKTYNTLGYQNSLIPSTAVNANGQEYELGLNVNERSFSTSQIGGIPSRISPEADRLLAEPFTGYHPAHLLNLDLRGIVRSNLQALRKEINERRKRGIDADLERRNLLDNIKEAMDEKRSEVEALEHKRRTAEEEFERLKEVTTTQKLASDAQIEKMEKELAKMRATMSESVQLMEQREMNTNIEYEQLTLRANALREELHTNVESMLNDVIRFKVHIQKGLEDYENFVVDEVEQELGGDTQLDEDAPMSTEEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias20-144Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000084
EMBL· GenBank· DDBJ
EAA61047.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001303
EMBL· GenBank· DDBJ
CBF76372.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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