Q5AHK2 · SSN3_CANAL
- ProteinSerine/threonine-protein kinase SSN3
- GeneSSN3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids608 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | CKM complex | |
Cellular Component | mediator complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | cyclin-dependent protein serine/threonine kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat kinase activity | |
Biological Process | cellular response to carbon dioxide | |
Biological Process | negative regulation of filamentous growth | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | nuclear-transcribed mRNA catabolic process, non-stop decay | |
Biological Process | positive regulation of transcription from RNA polymerase II promoter by galactose | |
Biological Process | protein destabilization | |
Biological Process | response to host iron concentration |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase SSN3
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5AHK2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312938 | 1-608 | Serine/threonine-protein kinase SSN3 | |||
Sequence: MSYSSASFRKLNNVGISQPSQTTTTTTSANQPQSQSQQQPLQQSQQQHLHMKPNPHIPHHQLPGTVGTRTSIPQPALMASNSILTLGPFKHRKDLTRESVLSTYQIMGYIAAGTYGKVYKAKLKSNKLNKTDDDSGIDGINNKDIFSESMNDLHHDNSSSIMINTTTNITINNSLPQFFAIKKFKSDNHHHHINNNNNGGNHLSKGNNSIHQDEVLHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMVFEFCEHDLLQIIHYQSHPDFKPIPCPTIKSLIWQILNGVTFLHKNWILHRDLKPANIMVSSQGVVKIGDLGLARKFKSPLQSLYTGDKVVVTIWYRAPELLLGTRHYTPAVDLWAVGCILAELLSLRPIFKGEEAKIDLNNKKSVPFQKNQLQKIIEILGTPTTDIWNNLNKYPEYLSFTQHFNQNYPNNLSNWFKLINGGNNQNSEKCLELLSGLLKYDPELRLTADQALLHPYFLELPKVNENAFEGLNYKYPNRKIYTDDNDIMTTAANNNNNNNNNNNNNNNNNNNNNNNNNNNSGHQLSQQQNVQIQQVHQMQQQIHSQQLQSHGANSTYKRSGIDDLPGGIRKKRG |
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-51 | Polar residues | ||||
Sequence: MSYSSASFRKLNNVGISQPSQTTTTTTSANQPQSQSQQQPLQQSQQQHLHM | ||||||
Region | 1-72 | Disordered | ||||
Sequence: MSYSSASFRKLNNVGISQPSQTTTTTTSANQPQSQSQQQPLQQSQQQHLHMKPNPHIPHHQLPGTVGTRTSI | ||||||
Domain | 104-492 | Protein kinase | ||||
Sequence: YQIMGYIAAGTYGKVYKAKLKSNKLNKTDDDSGIDGINNKDIFSESMNDLHHDNSSSIMINTTTNITINNSLPQFFAIKKFKSDNHHHHINNNNNGGNHLSKGNNSIHQDEVLHYTGISQSAIREMSLCRELNNKNITKLVDIILENKSIYMVFEFCEHDLLQIIHYQSHPDFKPIPCPTIKSLIWQILNGVTFLHKNWILHRDLKPANIMVSSQGVVKIGDLGLARKFKSPLQSLYTGDKVVVTIWYRAPELLLGTRHYTPAVDLWAVGCILAELLSLRPIFKGEEAKIDLNNKKSVPFQKNQLQKIIEILGTPTTDIWNNLNKYPEYLSFTQHFNQNYPNNLSNWFKLINGGNNQNSEKCLELLSGLLKYDPELRLTADQALLHPYF | ||||||
Compositional bias | 523-591 | Polar residues | ||||
Sequence: MTTAANNNNNNNNNNNNNNNNNNNNNNNNNNNSGHQLSQQQNVQIQQVHQMQQQIHSQQLQSHGANSTY | ||||||
Region | 523-608 | Disordered | ||||
Sequence: MTTAANNNNNNNNNNNNNNNNNNNNNNNNNNNSGHQLSQQQNVQIQQVHQMQQQIHSQQLQSHGANSTYKRSGIDDLPGGIRKKRG |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length608
- Mass (Da)68,962
- Last updated2017-05-10 v2
- Checksum1145A2C882CF3856
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-51 | Polar residues | ||||
Sequence: MSYSSASFRKLNNVGISQPSQTTTTTTSANQPQSQSQQQPLQQSQQQHLHM | ||||||
Compositional bias | 523-591 | Polar residues | ||||
Sequence: MTTAANNNNNNNNNNNNNNNNNNNNNNNNNNNSGHQLSQQQNVQIQQVHQMQQQIHSQQLQSHGANSTY |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017624 EMBL· GenBank· DDBJ | AOW27452.1 EMBL· GenBank· DDBJ | Genomic DNA |