Q5AHG6 · SCH9_CANAL
- ProteinSerine/threonine-protein kinase SCH9
- GeneSCH9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids787 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway (By similarity).
Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO2 levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO2 levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase SCH9
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5AHG6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Leads to reduced cell size and to sensitivity to rapamycin, caffeine and sodium dodecyl sulfate. Attenuates the virulence of in a mouse model of systemic candidiasis.
Miscellaneous
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000422106 | 1-787 | Serine/threonine-protein kinase SCH9 | |||
Sequence: MVDFAKSLFGFGNYKKESSSQSPTPPPSAHSSQEQHHKSNTEEYPQSHLSQQQHSHRYQPPHMSEQSHQFPQQQQQQQQSGTNKFFPKTLVSAAPTTAVANHSSVYGTTSTTTNNYPEAYLNQTFKNNIYNPQQQQQQQAQQPPPEQQQSSAPYQNSANIQQPYGNQWGSSQDQDANIITIDKTGNKLSPASRDSPIKGKLKVTILEAKDIFATQPYVVCSFESSEFVTNAPDSYGKSPVSSFGHNNNQGHNGPRNMYNSNHGPSPKALPMKNSGNLFGQRPSMYQRQLSTPHLNLPNDSSNPIWNHDTIFDVVGSKSELDISVYDGARDDAFLGHVRISPSTDKNNKNESEWLQLGARITGETVSSGHIKIKWEYTSFDNNIKRSYGPDDFHFLRLLGKGTFGQVFQVRKKDTNRVYAMKILSKKVIVKKKEIAHTIGERNILVRTSAASSPFIVGLKFSFQTPSDLFLVTDFMSGGELFFHLQKEGRFNEDRSKFYTAELILALEHLHDNDIVYRDLKPENILLDANGHIALCDFGLSKADLNMDGTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLIFEMTCGWSPFHAENTQQMYKNIAFGKVRFPKDVLSPEGRSFVKGLLNRNPKHRLGATDDARELKAHPFFADIDWDLLRAKNIPPPFKPHIVSETDISNFDTEFTSENTSALKRQMEMATTPLSPGIQANFKGFTYVDDSTMDDHFARSYRANAFRPPGSFIPGDPNLPPDEEVLAEQIEEEDEMEVDEDQHMDDEFVNGRFDL |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-82 | Disordered | ||||
Sequence: MVDFAKSLFGFGNYKKESSSQSPTPPPSAHSSQEQHHKSNTEEYPQSHLSQQQHSHRYQPPHMSEQSHQFPQQQQQQQQSGT | ||||||
Compositional bias | 13-34 | Polar residues | ||||
Sequence: NYKKESSSQSPTPPPSAHSSQE | ||||||
Compositional bias | 44-82 | Polar residues | ||||
Sequence: YPQSHLSQQQHSHRYQPPHMSEQSHQFPQQQQQQQQSGT | ||||||
Region | 132-172 | Disordered | ||||
Sequence: PQQQQQQQAQQPPPEQQQSSAPYQNSANIQQPYGNQWGSSQ | ||||||
Domain | 182-354 | C2 | ||||
Sequence: DKTGNKLSPASRDSPIKGKLKVTILEAKDIFATQPYVVCSFESSEFVTNAPDSYGKSPVSSFGHNNNQGHNGPRNMYNSNHGPSPKALPMKNSGNLFGQRPSMYQRQLSTPHLNLPNDSSNPIWNHDTIFDVVGSKSELDISVYDGARDDAFLGHVRISPSTDKNNKNESEWL | ||||||
Compositional bias | 238-267 | Polar residues | ||||
Sequence: SPVSSFGHNNNQGHNGPRNMYNSNHGPSPK | ||||||
Region | 238-280 | Disordered | ||||
Sequence: SPVSSFGHNNNQGHNGPRNMYNSNHGPSPKALPMKNSGNLFGQ | ||||||
Domain | 392-653 | Protein kinase | ||||
Sequence: FHFLRLLGKGTFGQVFQVRKKDTNRVYAMKILSKKVIVKKKEIAHTIGERNILVRTSAASSPFIVGLKFSFQTPSDLFLVTDFMSGGELFFHLQKEGRFNEDRSKFYTAELILALEHLHDNDIVYRDLKPENILLDANGHIALCDFGLSKADLNMDGTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLIFEMTCGWSPFHAENTQQMYKNIAFGKVRFPKDVLSPEGRSFVKGLLNRNPKHRLGATDDARELKAHPFF | ||||||
Domain | 654-729 | AGC-kinase C-terminal | ||||
Sequence: ADIDWDLLRAKNIPPPFKPHIVSETDISNFDTEFTSENTSALKRQMEMATTPLSPGIQANFKGFTYVDDSTMDDHF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length787
- Mass (Da)88,746
- Last updated2017-05-10 v2
- Checksum68669E0EC178936C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 13-34 | Polar residues | ||||
Sequence: NYKKESSSQSPTPPPSAHSSQE | ||||||
Compositional bias | 44-82 | Polar residues | ||||
Sequence: YPQSHLSQQQHSHRYQPPHMSEQSHQFPQQQQQQQQSGT | ||||||
Compositional bias | 238-267 | Polar residues | ||||
Sequence: SPVSSFGHNNNQGHNGPRNMYNSNHGPSPK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017624 EMBL· GenBank· DDBJ | AOW27421.1 EMBL· GenBank· DDBJ | Genomic DNA |