Q5AG77 · GAP1_CANAL

Function

function

Amino-acid permease that coordinates external nitrogen source response and morphogenesis (PubMed:12949183, PubMed:21764911, PubMed:28028545).
Is capable of transporting several structurally unrelated amino acids such as leucine and phenylalanine, though with a lower capacity than the GAP2 and GAP6 permeases (PubMed:21764911).
Has citrulline import activity (PubMed:12949183).
GAP1 is also able to transport thialysine, and thus probably also lysine (PubMed:21764911).
Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA (PubMed:21764911).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentfungal-type cell wall
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionamino acid transmembrane transporter activity
Biological Processamino acid transmembrane transport
Biological Processamino acid transport
Biological Processfilamentous growth
Biological Processfilamentous growth of a population of unicellular organisms

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Amino-acid permease GAP1

Gene names

    • Name
      GAP1
    • Ordered locus names
      CAALFM_C502790CA

Organism names

Accessions

  • Primary accession
    Q5AG77
  • Secondary accessions
    • Q8TGV8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane82-102Helical
Transmembrane120-142Helical
Transmembrane150-170Helical
Transmembrane190-210Helical
Transmembrane216-236Helical
Transmembrane263-283Helical
Transmembrane302-322Helical
Transmembrane343-363Helical
Transmembrane402-422Helical
Transmembrane427-447Helical
Transmembrane481-501Helical
Transmembrane510-530Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Decreases two fold the citrulline uptake (PubMed:12949183).
Leads to defective hyphal formation in solid hyphal-inducing media and exhibits less hyphal clumps when induced by N-acetylglucosamine (PubMed:12949183).

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004398061-582Amino-acid permease GAP1
Glycosylation8N-linked (GlcNAc...) asparagine
Glycosylation183N-linked (GlcNAc...) asparagine
Glycosylation370N-linked (GlcNAc...) asparagine
Glycosylation448N-linked (GlcNAc...) asparagine
Glycosylation462N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression is under control of the CSY1 amino-acid sensor (PubMed:28028545).
Expression is induced by N-acetylglucosamine (PubMed:12949183).
Expression is also regulated by CPH1-mediated RAS1 signaling but is independent of EFG1 (PubMed:12949183).
Induced during biofilm development (PubMed:21414038, PubMed:22265407, PubMed:23572557).
Induced upon internalization by host macrophages (PubMed:15470236).
Expression is down-regulated by growth in alkaline conditions (PubMed:15554973).
Expression is also controlled by the nitrogen-dependent GATA-type transcriptional activator GAT1 (PubMed:14617156).

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-28Disordered
Compositional bias11-28Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    582
  • Mass (Da)
    63,951
  • Last updated
    2005-04-26 v1
  • Checksum
    72CC98F97D0E4053
MLHKKETNDTFVQLNRSPSTGEQKSSGIWSSIKDSFKPALPQDKLTGVDDIPDRELTDIERININAANSNLQRKLKTRHLQMIAIGSSIGTGLFVGTGGALSTGGPAAIVLAWAISAISVFMTMQGLGELAVAFPVSGGFNLYASKFLEPGIGFAVGWNYFLQFFVLLPLELVAGAITIKYWNASINSDVFVIIFWFVVLVITMLGVRWYGEAELVFCTIKVIAVIGFIILGIVLICGGGPNHEFIGGKYWREPGPFANSFKGFASSLITAAFSFGGTEMIALTASESSNVRHALPKAIKQVFWRIVIFYLGSIIMIATLVPYNDKRLLGSSSVDVTASPFTIAIVNGGIKGLPSVINAVILISVLSVGNASVYATSRTLNSLAEQGMAPKWTGYIDRAGRPLFAILITNVFGLFALIAADNEKQVVAFNWLLALSGLSSIFTWMSINLSHIRFRRAMKVQNRSLTELPFVAQSGVWGSYFGLTLNILYLIAQFYIGLFPVGGKPNAYDFFLAYLGVPVILASWIGYKIWKRDWTLFIRAKDIDLDTGRINVDLDLLQQEIAEEKAQLAEKPFYIRIYRFWC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias11-28Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017627
EMBL· GenBank· DDBJ
AOW29704.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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