Q5A847 · JHD1_CANAL
- ProteinJmjC domain-containing histone demethylation protein 1
- GeneJHD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Catalytic activity
- N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl36-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2
RHEA-COMP:9787 CHEBI:61976 Position: 36+ 2 CHEBI:16810 + 2 CHEBI:15379 = RHEA-COMP:9785 CHEBI:29969 Position: 36+ 2 CHEBI:16842 + 2 CHEBI:30031 + 2 CHEBI:16526
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone demethylase activity | |
Molecular Function | histone H3K36me/H3K36me2 demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription coregulator activity | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameJmjC domain-containing histone demethylation protein 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A847
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000226793 | 1-478 | JmjC domain-containing histone demethylation protein 1 | |||
Sequence: MPINSESCPLCKVHSNTIKKEDEDEEDNKTSWIQCSKCKVWYHVHCLDLPTDEIDQIVIYHCPECVPKYGESTYKRKSKRARVSIDYQSLNEGDTFAIDKSSHFHLHNFLNFKGETNINVIDKLTKTYALNTQMEKPILIPQADLSKNGMQLPIEKNEITIDYITDCCGEDTPLEVMDVISQQGISPPWKLKQWREYFKTNEEKRDRIRNVISLEISDVAKLGVDFTRPKCVRDMDVVDRVWIEEDEQKRSKVTKYCLMSVKNSFTDFHIDFGGTSVYYTVLSGAKTFLFFPPTDNNLELYKSWCLEPSQNFIWYPEYTITKNKKKIKPTGGFKVDLQPGDLFIIPSGWIHAVHTPQDSIVIGGNYLTIRDMVMQLKINEIERETKVPTKFRFPMFNKVLWLTAWYYYNHQNEFQSDIGEDEDGNAILTRLIGHLQGHLELSKTNATAKRSIPKTIGKPMVFINKLLAWKEDLYGTAV |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 5-68 | PHD-type | ||||
Sequence: SESCPLCKVHSNTIKKEDEDEEDNKTSWIQCSKCKVWYHVHCLDLPTDEIDQIVIYHCPECVPK | ||||||
Domain | 217-383 | JmjC | ||||
Sequence: SDVAKLGVDFTRPKCVRDMDVVDRVWIEEDEQKRSKVTKYCLMSVKNSFTDFHIDFGGTSVYYTVLSGAKTFLFFPPTDNNLELYKSWCLEPSQNFIWYPEYTITKNKKKIKPTGGFKVDLQPGDLFIIPSGWIHAVHTPQDSIVIGGNYLTIRDMVMQLKINEIER |
Domain
The JmjC domain mediates the demethylation activity.
Sequence similarities
Belongs to the JHDM1 histone demethylase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)55,460
- Last updated2005-04-26 v1
- Checksum5DA6D1654795CF5D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017630 EMBL· GenBank· DDBJ | AOW30842.1 EMBL· GenBank· DDBJ | Genomic DNA |