Q5A847 · JHD1_CANAL

Function

function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

147850100150200250300350400450
TypeIDPosition(s)Description
Binding site266substrate
Binding site269Fe cation (UniProtKB | ChEBI); catalytic
Binding site271Fe cation (UniProtKB | ChEBI); catalytic
Binding site286substrate
Binding site351Fe cation (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone demethylase activity
Molecular Functionhistone H3K36me/H3K36me2 demethylase activity
Molecular Functionmetal ion binding
Molecular Functiontranscription coregulator activity
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    JmjC domain-containing histone demethylation protein 1
  • EC number
  • Alternative names
    • [Histone-H3]-lysine-36 demethylase 1

Gene names

    • Name
      JHD1
    • ORF names
      CaO19.10791, CaO19.3281
    • Ordered locus names
      CAALFM_CR00750CA

Organism names

Accessions

  • Primary accession
    Q5A847
  • Secondary accessions
    • A0A1D8PRT4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002267931-478JmjC domain-containing histone demethylation protein 1

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, domain.

TypeIDPosition(s)Description
Zinc finger5-68PHD-type
Domain217-383JmjC

Domain

The JmjC domain mediates the demethylation activity.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    55,460
  • Last updated
    2005-04-26 v1
  • Checksum
    5DA6D1654795CF5D
MPINSESCPLCKVHSNTIKKEDEDEEDNKTSWIQCSKCKVWYHVHCLDLPTDEIDQIVIYHCPECVPKYGESTYKRKSKRARVSIDYQSLNEGDTFAIDKSSHFHLHNFLNFKGETNINVIDKLTKTYALNTQMEKPILIPQADLSKNGMQLPIEKNEITIDYITDCCGEDTPLEVMDVISQQGISPPWKLKQWREYFKTNEEKRDRIRNVISLEISDVAKLGVDFTRPKCVRDMDVVDRVWIEEDEQKRSKVTKYCLMSVKNSFTDFHIDFGGTSVYYTVLSGAKTFLFFPPTDNNLELYKSWCLEPSQNFIWYPEYTITKNKKKIKPTGGFKVDLQPGDLFIIPSGWIHAVHTPQDSIVIGGNYLTIRDMVMQLKINEIERETKVPTKFRFPMFNKVLWLTAWYYYNHQNEFQSDIGEDEDGNAILTRLIGHLQGHLELSKTNATAKRSIPKTIGKPMVFINKLLAWKEDLYGTAV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017630
EMBL· GenBank· DDBJ
AOW30842.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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