Q5A761 · CCR4_CANAL
- ProteinCCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- GeneCCR4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids787 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).
Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
Catalytic activity
Cofactor
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A761
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000290607 | 1-787 | CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 | |||
Sequence: MNITNKFQHTPIQGQPQSNLQAQQILLSQLHQGQAQQQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESLNQNIYQNNYQRAQPSLQQQFFPQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPSSQQFYSQQQASVLQQQQQQQIQLQSAHQQQSSLLNMNSINVDNPNSVYWQHQQQLCQISRGSNVPHYYARQYASNSRKAKNPYSEVKSVGLVEATRSMVASLEDEEEKKKKPINYQGTPTTSAALLHNKKSTQDIFEDDSMEEQRMRLKTQGKQLWCQLDLSGQGLVNISSKLFHYDFLESLYLSNNKLNSIPSSISKLRNLRTLDLSHNRINELPEELGLCFNLRYLFLFDNNIKTLPYSFGNMIELLFIGIEGNPLEPSIANLIAEKGTKELIATLRDQTTVKRTPKPRCWLTLEDDGEVVDSDEVYKVEPESSDNFTVLSYNTLCQHYATPKMYKFTPSWALQWDYRKNLLEKEVLNYNTDIVCMQEVETKTFQEFWLPVMTANGYKGYFFSKTRSKTMSETDSKKVDGCATFFKNDKFSLIHKQNFEYNSVCMGSDKYKKTKDLFNRFMNKDNIALISYLQHKESGEKIAVVNTHLHWDPAFNDVKALQVGILLEELQGIIKKYRHTNSNEDIKNSSIVVCGDFNSVKDSAVYQLFSTGASKGHEDMNGRDYGKFTEDGFHHPFKLKSAYEAVGELPFTNLTPAFTDNIDYIWYSTPTLQVKGLLGGVDEEYTSHSIGFPDANFPSDHVPILAKFQLKKGKKNHSV |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 37-70 | Disordered | ||||
Sequence: QQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESL | ||||||
Region | 92-137 | Disordered | ||||
Sequence: PQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPS | ||||||
Repeat | 291-313 | LRR 1 | ||||
Sequence: QLWCQLDLSGQGLVNISSKLFHY | ||||||
Repeat | 315-336 | LRR 2 | ||||
Sequence: FLESLYLSNNKLNSIPSSISKL | ||||||
Repeat | 338-359 | LRR 3 | ||||
Sequence: NLRTLDLSHNRINELPEELGLC | ||||||
Repeat | 361-382 | LRR 4 | ||||
Sequence: NLRYLFLFDNNIKTLPYSFGNM | ||||||
Repeat | 384-406 | LRR 5 | ||||
Sequence: ELLFIGIEGNPLEPSIANLIAEK |
Sequence similarities
Belongs to the CCR4/nocturin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length787
- Mass (Da)90,325
- Last updated2017-04-12 v2
- Checksum44A05726795171FA
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 562 | in Ref. 4; CAA21997 | ||||
Sequence: I → V | ||||||
Sequence conflict | 748 | in Ref. 4; CAA21997 | ||||
Sequence: G → R | ||||||
Sequence conflict | 784 | in Ref. 4; CAA21997 | ||||
Sequence: N → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017623 EMBL· GenBank· DDBJ | AOW26462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL033501 EMBL· GenBank· DDBJ | CAA21997.1 EMBL· GenBank· DDBJ | Genomic DNA |