Q5A748 · SNX3_CANAL
- ProteinSorting nexin-3
- GeneSNX3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids157 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 77 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 101 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 117 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | retromer complex | |
Molecular Function | phosphatidylinositol-3-phosphate binding | |
Biological Process | endocytic recycling | |
Biological Process | late endosome to Golgi transport | |
Biological Process | protein transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSorting nexin-3
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A748
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Prevacuolar compartment membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000238584 | 1-157 | Sorting nexin-3 | |||
Sequence: MSKPFQPISDVINTSPKNKSQSFNEIYGEPENFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDPKQIIY |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MSKPFQPISDVINTSPKNKSQ | ||||||
Domain | 32-152 | PX | ||||
Sequence: NFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDP |
Domain
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Sequence similarities
Belongs to the sorting nexin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length157
- Mass (Da)18,362
- Last updated2017-03-15 v2
- Checksum40A7D1A42F4FA091
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL033501 EMBL· GenBank· DDBJ | CAA21987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP017623 EMBL· GenBank· DDBJ | AOW26472.1 EMBL· GenBank· DDBJ | Genomic DNA |