Q5A748 · SNX3_CANAL

Function

function

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).

Features

Showing features for binding site.

115720406080100120140
TypeIDPosition(s)Description
Binding site75a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)
Binding site77a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)
Binding site101a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)
Binding site117a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Cellular ComponentGolgi membrane
Cellular Componentretromer complex
Molecular Functionphosphatidylinositol-3-phosphate binding
Biological Processendocytic recycling
Biological Processlate endosome to Golgi transport
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sorting nexin-3

Gene names

    • Name
      SNX3
    • ORF names
      Ca41C10.03, CaO19.12580, CaO19.5114
    • Ordered locus names
      CAALFM_C108340CA

Organism names

Accessions

  • Primary accession
    Q5A748
  • Secondary accessions
    • A0A1D8PEA7
    • O94037

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Golgi apparatus membrane
; Peripheral membrane protein
Prevacuolar compartment membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002385841-157Sorting nexin-3

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Domain32-152PX

Domain

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similarities

Belongs to the sorting nexin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    18,362
  • Last updated
    2017-03-15 v2
  • Checksum
    40A7D1A42F4FA091
MSKPFQPISDVINTSPKNKSQSFNEIYGEPENFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDPKQIIY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL033501
EMBL· GenBank· DDBJ
CAA21987.1
EMBL· GenBank· DDBJ
Genomic DNA
CP017623
EMBL· GenBank· DDBJ
AOW26472.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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