Q5A6P6 · QDR1_CANAL
- ProteinMFS antiporter QDR1
- GeneQDR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids509 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity | |
Biological Process | lipid homeostasis | |
Biological Process | membrane raft assembly | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMFS antiporter QDR1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A6P6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Preferentially localizes to membrane rafts.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-41 | Cytoplasmic | ||||
Sequence: MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKL | ||||||
Transmembrane | 42-62 | Helical; Name=1 | ||||
Sequence: LLIIVLSLVGFWSAISSPIYF | ||||||
Topological domain | 63-75 | Extracellular | ||||
Sequence: PALPTLTKYFNTT | ||||||
Transmembrane | 76-96 | Helical; Name=2 | ||||
Sequence: PSVMNISVVAYLIFQGIAPTI | ||||||
Topological domain | 97-106 | Cytoplasmic | ||||
Sequence: SSNLADTFGR | ||||||
Transmembrane | 107-129 | Helical; Name=3 | ||||
Sequence: RPVILGSIIVFCAVCIAISQTNV | ||||||
Topological domain | 130-132 | Extracellular | ||||
Sequence: YWL | ||||||
Transmembrane | 133-155 | Helical; Name=4 | ||||
Sequence: LALLRCFQAAGIAPVFAISSGVA | ||||||
Topological domain | 156-169 | Cytoplasmic | ||||
Sequence: GDICTPANRGGMVG | ||||||
Transmembrane | 170-190 | Helical; Name=5 | ||||
Sequence: AVSGLQLAGNGIGGLVGAALI | ||||||
Topological domain | 191-197 | Extracellular | ||||
Sequence: SGFHTWR | ||||||
Transmembrane | 198-218 | Helical; Name=6 | ||||
Sequence: AIFIFLAIGGGVTFIFAFLVL | ||||||
Topological domain | 219-278 | Cytoplasmic | ||||
Sequence: AETSRRIVGNGSIRPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKE | ||||||
Transmembrane | 279-299 | Helical; Name=7 | ||||
Sequence: VFCTLLPSGMHFAAWTVSLTS | ||||||
Topological domain | 300-312 | Extracellular | ||||
Sequence: LSTELESAKYNYS | ||||||
Transmembrane | 313-333 | Helical; Name=8 | ||||
Sequence: VMKVGLVYLPQGIACFIGSLI | ||||||
Topological domain | 334-370 | Cytoplasmic | ||||
Sequence: AGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASR | ||||||
Transmembrane | 371-391 | Helical; Name=9 | ||||
Sequence: LTLTIVPLAMMVIGLSAFGWC | ||||||
Topological domain | 392-397 | Extracellular | ||||
Sequence: LEYKKP | ||||||
Transmembrane | 398-418 | Helical; Name=10 | ||||
Sequence: IISIIISTILISFSASVMMSI | ||||||
Topological domain | 419-432 | Cytoplasmic | ||||
Sequence: CTTMLVDLYPKQSG | ||||||
Transmembrane | 433-453 | Helical; Name=11 | ||||
Sequence: ASASCVNLMRCWLAALFTGVL | ||||||
Topological domain | 454-455 | Extracellular | ||||
Sequence: DK | ||||||
Transmembrane | 456-476 | Helical; Name=12 | ||||
Sequence: IISALGLGGTYTLLTGICLLT | ||||||
Topological domain | 477-509 | Cytoplasmic | ||||
Sequence: DLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Leads to defects in biofilm architecture.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000431599 | 1-509 | MFS antiporter QDR1 | |||
Sequence: MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKLLLIIVLSLVGFWSAISSPIYFPALPTLTKYFNTTPSVMNISVVAYLIFQGIAPTISSNLADTFGRRPVILGSIIVFCAVCIAISQTNVYWLLALLRCFQAAGIAPVFAISSGVAGDICTPANRGGMVGAVSGLQLAGNGIGGLVGAALISGFHTWRAIFIFLAIGGGVTFIFAFLVLAETSRRIVGNGSIRPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKEVFCTLLPSGMHFAAWTVSLTSLSTELESAKYNYSVMKVGLVYLPQGIACFIGSLIAGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASRLTLTIVPLAMMVIGLSAFGWCLEYKKPIISIIISTILISFSASVMMSICTTMLVDLYPKQSGASASCVNLMRCWLAALFTGVLDKIISALGLGGTYTLLTGICLLTDLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY |
Expression
Induction
Expression is repressed by caspofungin and during chlamydospore formation. Also regulated during white-opaque switch, and by NRG1, TUP1 and HAP43.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the major facilitator superfamily. CAR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length509
- Mass (Da)55,432
- Last updated2005-04-26 v1
- Checksum612FFB8DA3E57073
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017630 EMBL· GenBank· DDBJ | AOW31159.1 EMBL· GenBank· DDBJ | Genomic DNA |