Q5A387 · LCMT1_CANAL
- ProteinLeucine carboxyl methyltransferase 1
- GenePPM1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids367 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Catalytic activity
- [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 84 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 109 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 132 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 187-188 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: DL | ||||||
Binding site | 212 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | protein C-terminal leucine carboxyl O-methyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine carboxyl methyltransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A387
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000226124 | 1-367 | Leucine carboxyl methyltransferase 1 | |||
Sequence: MLSPQDRQDKLVRATDLDALSCKYSINRNLYLNPPDEFVKDLVESYQRYLQYCVGYTGLSSSRALKGLFQEKKMPIINRGSYLRTRAIDQVVNKFIGEFKDRCQIVSLGSGSDTRAFQIFKSHANVIYHEIDFPESAKVKKLAILQNPVIRELVGTNETSPLINNKEQFESYSSELHTEKYHLHGIDLRTLKKPDSQIKGFQPEVPTLVISECVLCYLSPDEYQRTMNYWTEIADQNYMGFLIYEPMSLNDQFGETMTLNLQSRGLNLQTFSKYPDLISRKKFLEESCHLKNLRLTDMSYIGGYKVRQDGREWIDHKEMGRINKLEMIDEIEEIRLLLEHYCLIYGEYTEEKTLNFKGIDTWSWILS |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the methyltransferase superfamily. LCMT family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length367
- Mass (Da)42,896
- Last updated2005-04-26 v1
- Checksum807A33E30586DE90
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017630 EMBL· GenBank· DDBJ | AOW31501.1 EMBL· GenBank· DDBJ | Genomic DNA |