Q5A312 · ALS7_CANAL
- ProteinAgglutinin-like protein 7
- GeneALS7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1568 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Miscellaneous
ALS7 gene corresponds to a hypermutable contingency locus meaning that the diversity of ALS7 proteins provide C.albicans with a large and flexible repertoire of similar but non-identical surface proteins which may be important not only for adhesion but also for evasion of host defenses.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | fungal-type cell wall | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | cell adhesion molecule binding | |
Biological Process | cell adhesion involved in multi-species biofilm formation | |
Biological Process | cell adhesion involved in single-species biofilm formation | |
Biological Process | cell-cell adhesion |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAgglutinin-like protein 7
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ5A312
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Note: Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Keywords
- Cellular component
Phenotypes & Variants
Miscellaneous
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_0000420226 | 19-1548 | Agglutinin-like protein 7 | ||
Disulfide bond | 74↔151 | ||||
Disulfide bond | 97↔113 | ||||
Disulfide bond | 206↔299 | ||||
Disulfide bond | 228↔257 | ||||
Glycosylation | 559 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 851 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 988 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 1188 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 1284 | N-linked (GlcNAc...) asparagine | |||
Lipidation | 1548 | GPI-anchor amidated serine | |||
Propeptide | PRO_0000420227 | 1549-1568 | Removed in mature form | ||
Post-translational modification
The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
Keywords
- PTM
PTM databases
Expression
Induction
Highly expressed in biofilms and during candidiasis infection dissemination.
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 403-434 | ALS 1 | |||
Repeat | 441-471 | ALS 2 | |||
Repeat | 476-507 | ALS 3 | |||
Repeat | 512-543 | ALS 4 | |||
Region | 546-662 | Disordered | |||
Region | 721-743 | Disordered | |||
Region | 767-834 | Disordered | |||
Region | 860-1030 | Disordered | |||
Region | 1046-1097 | Disordered | |||
Region | 1194-1220 | Disordered | |||
Region | 1271-1305 | Disordered | |||
Domain
Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter domain that is relatively variable in length and sequence across the family.
Sequence similarities
Belongs to the ALS family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,568
- Mass (Da)167,667
- Last updated2017-03-15 v2
- ChecksumE462A221F517FAF4
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 2 | in Ref. 4; AAP51179 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017625 EMBL· GenBank· DDBJ | AOW28639.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY296650 EMBL· GenBank· DDBJ | AAP51179.1 EMBL· GenBank· DDBJ | Genomic DNA |